Hepatosplenomegaly Is Associated with Low Regulatory and Th2 Responses to Schistosome Antigens in Childhood Schistosomiasis and Malaria Coinfection
In: Infection and Immunity, Jg. 76 (2008), Heft 5, S. 2212-2218
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Zugriff:
Hepatosplenomegaly among Kenyan schoolchildren has been shown to be exacerbated where there is transmission of both Schistosoma mansoni and Plasmodium falciparum . This highly prevalent and chronic morbidity often occurs in the absence of ultrasound-detectable periportal fibrosis and may be due to immunological inflammation. For a cohort of school-age children, whole-blood cultures were stimulated with S. mansoni soluble egg antigen (SEA) or soluble worm antigen (SWA). Responses to SWA were found to be predominantly Th2 cytokines; however, they were not significantly associated with either hepatosplenomegaly or infection with S. mansoni or P. falciparum . In comparison, SEA-specific Th2 cytokine responses were low, and the levels were negatively correlated with S. mansoni infection intensities and were lower among children who were coinfected with P. falciparum . Tumor necrosis factor alpha levels in response to stimulation with SEA were high, and a negative association between presentation with hepatomegaly and the levels of the regulatory cytokines interleukin-6 and transforming growth factor β 1 suggests that a possible mechanism for childhood hepatomegaly in areas where both malaria and schistosomiasis are endemic is poor regulation of an inflammatory response to schistosome eggs.
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Hepatosplenomegaly Is Associated with Low Regulatory and Th2 Responses to Schistosome Antigens in Childhood Schistosomiasis and Malaria Coinfection
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Autor/in / Beteiligte Person: | Wilson, Shona ; Jones, Frances M. ; Mwatha, Joseph K. ; Kimani, Gachuhi ; Booth, Mark ; Kariuki, H. Curtis ; Vennervald, Birgitte J. ; Ouma, John H. ; Muchiri, Eric ; Dunne, David W. |
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Zeitschrift: | Infection and Immunity, Jg. 76 (2008), Heft 5, S. 2212-2218 |
Veröffentlichung: | American Society for Microbiology, 2008 |
Medientyp: | academicJournal |
ISSN: | 0019-9567 |
DOI: | 10.1128/iai.01433-07 |
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