A novel SARS-CoV-2 related coronavirus in bats from Cambodia
In: ISSN: 2041-1723, 2021
Online
academicJournal
Zugriff:
International audience ; Knowledge of the origin and reservoir of the coronavirus responsible for the ongoing COVID-19 pandemic is still fragmentary. To date, the closest relatives to SARS-CoV-2 have been detected in Rhinolophus bats sampled in the Yunnan province, China. Here we describe the identification of SARS-CoV-2 related coronaviruses in two Rhinolophus shameli bats sampled in Cambodia in 2010. Metagenomic sequencing identifies nearly identical viruses sharing 92.6% nucleotide identity with SARS-CoV-2. Most genomic regions are closely related to SARS-CoV-2, with the exception of a region of the spike, which is not compatible with human ACE2-mediated entry. The discovery of these viruses in a bat species not found in China indicates that SARS-CoV-2 related viruses have a much wider geographic distribution than previously reported, and suggests that Southeast Asia represents a key area to consider for future surveillance for coronaviruses.
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A novel SARS-CoV-2 related coronavirus in bats from Cambodia
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| Autor/in / Beteiligte Person: | Delaune, Deborah ; Hul, Vibol ; Karlsson, Erik, A. ; Hassanin, Alexandre, A. ; Ou, Tey Putita ; Baidaliuk, Artem ; Gámbaro, Fabiana ; Prot, Matthieu ; Tu, Vuong Tan ; Chea, Sokha ; Keatts, Lucy ; Mazet, Jonna ; Johnson, Christine, K. ; Buchy, Philippe ; Dussart, Philippe ; Goldstein, Tracey ; Simon-Loriere, Etienne ; Duong, Veasna ; Génomique évolutive des virus à ARN - Evolutionary genomics of RNA viruses ; Institut Pasteur Paris (IP)-Université Paris Cité (UPCité) ; Institut de Recherche Biomédicale des Armées Brétigny-sur-Orge (IRBA) ; Paris-Saclay, Université ; Unité de Virologie / Virology Unit Phnom Penh ; Institut Pasteur du Cambodge ; Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP) ; Unité des Virus Emergents (UVE) ; Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Institut de Systématique, Evolution, Biodiversité (ISYEB ) ; Muséum national d'Histoire naturelle (MNHN)-École Pratique des Hautes Études (EPHE) ; Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA) ; Université Paris Cité (UPCité) ; Wildlife Conservation Society Phnom Penh, Cambodia ; Wildlife Conservation Society (WCS) ; University of California Davis (UC Davis) ; University of California (UC) ; This study was made possible by the generous support of the American people through the United States Agency for International Development (USAID) Emerging Pandemic Threats PREDICT project (cooperative agreement number GHN-A-OO-09-00010-00 and AID-OAA-A-14-00102), with a specific extension for the testing reported here. V.H. is supported by a scholarship from the French Government (BGF) for his Ph.D. E.S.L. acknowledges funding from the French Government’s Investissement d’Avenir program, ‘INCEPTION’ (ANR-16-CONV-0005), and Laboratoire d’Excellence ‘Integrative Biology of Emerging Infectious Diseases’ (ANR-10-LABX-62-IBEID). In 2010, the fieldwork was supported by the National Authority for Preah Vihear, UNESCO, “Société des amis du Muséum et du Jardin des Plantes”, and the Muséum national d’Histoire naturelle. ; ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016) ; ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010) |
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| Zeitschrift: | ISSN: 2041-1723, 2021 |
| Veröffentlichung: | HAL CCSD ; Nature Publishing Group, 2021 |
| Medientyp: | academicJournal |
| DOI: | 10.1038/s41467-021-26809-4 |
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