Intraocular Pressure, Glaucoma, and Dietary Caffeine Consumption
In: ISSN: 0161-6420, 2021
Online
academicJournal
Zugriff:
Supplemental material available at www.aaojournal.org. ; International audience ; Purpose: We examined the association of habitual caffeine intake with intraocular pressure (IOP) and glaucoma and whether genetic predisposition to higher IOP modified these associations. We also assessed whether genetic predisposition to higher coffee consumption was related to IOP.Design: Cross-sectional study in the UK Biobank.Participants: We included 121 374 participants (baseline ages, 39-73 years) with data on coffee and tea intake (collected 2006-2010) and corneal-compensated IOP measurements in 2009. In a subset of 77 906 participants with up to 5 web-based 24-hour-recall food frequency questionnaires (2009-2012), we evaluated total caffeine intake. We also assessed the same relationships with glaucoma (9286 cases and 189 763 controls).Methods: We evaluated multivariable-adjusted associations with IOP using linear regression and with glaucoma using logistic regression. For both outcomes, we examined gene-diet interactions using a polygenic risk score (PRS) that combined the effects of 111 genetic variants associated with IOP. We also performed Mendelian randomization using 8 genetic variants associated with coffee intake to assess potential causal effects of coffee consumption on IOP.Main outcome measures: Intraocular pressure and glaucoma.Results: Mendelian randomization analysis did not support a causal effect of coffee drinking on IOP (P > 0.1). Greater caffeine intake was associated weakly with lower IOP: the highest (≥232 mg/day) versus lowest (<87 mg/day) caffeine consumption was associated with a 0.10-mmHg lower IOP (Ptrend = 0.01). However, the IOP PRS modified this association: among those in the highest IOP PRS quartile, consuming > 480 mg/day versus < 80 mg/day was associated with a 0.35-mmHg higher IOP (Pinteraction = 0.01). The relationship between caffeine intake and glaucoma was null (P ≥ 0.1). However, the IOP PRS also modified this relationship: compared with those in the lowest IOP PRS ...
| Titel: |
Intraocular Pressure, Glaucoma, and Dietary Caffeine Consumption
|
|---|---|
| Autor/in / Beteiligte Person: | Kim, Jihye ; Aschard, Hugues ; Kang, Jae ; Lentjes, Marleen ; Do, Ron ; Wiggs, Janey ; Khawaja, Anthony ; Pasquale, Louis ; Risk Factors For Glaucoma Collaboration∗, Modifiable ; Harvard T.H. Chan School of Public Health ; Département de Biologie Computationnelle - Department of Computational Biology ; Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS) ; Harvard Medical School Boston (HMS) ; University, Örebro ; Icahn School of Medicine at Mount Sinai New York (MSSM) ; University of Balamand Liban (UOB) ; UCL Institute of Ophthalmology ; University College of London London (UCL) ; Supported by the National Eye Institute, National Institutes of Health, Bethesda, Maryland (grant no.: R01 EY015473) ; The Eye and Vision Research Institute of New York Eye and Ear Infirmary at Mount Sinai, New York, New York ; UK Research and Innovation Future Leaders Fellowship (A.P.K.) ; Moorfields Eye Charity Career Development Fellowship, London, United Kingdom (A.P.K.) ; and Alcon Research Institute Young Investigator Award (A.P.K.). |
| Link: | |
| Zeitschrift: | ISSN: 0161-6420, 2021 |
| Veröffentlichung: | HAL CCSD ; Elsevier, 2021 |
| Medientyp: | academicJournal |
| DOI: | 10.1016/j.ophtha.2020.12.009 |
| Schlagwort: |
|
| Sonstiges: |
|