Assessing the Contribution of Active and Passive Stresses in C. elegans Elongation
In: ISSN: 0031-9007, 2018
Online
academicJournal
Zugriff:
International audience ; The role of the actomyosin network is investigated in the elongation of C. elegans during embryonic morphogenesis. We present a model of active elongating matter that combines prestress and passive stress in nonlinear elasticity. Using this model we revisit recently published data from laser ablation experiments to account for why cells under contraction can lead to an opening fracture. By taking into account the specific embryo geometry, we obtain quantitative predictions for the contractile forces exerted by the molecular motors myosin II for an elongation up to 70% of the initial length. This study demonstrates the importance of active processes in embryonic morphogenesis and the interplay between geometry and nonlinear mechanics during morphological events. In particular, it outlines the role of each connected layer of the epidermis compressed by an apical extracellular matrix that distributes the stresses during elongation.
Titel: |
Assessing the Contribution of Active and Passive Stresses in C. elegans Elongation
|
---|---|
Autor/in / Beteiligte Person: | Ben Amar, Martine ; Qiuyang-Qu, Paul ; Vuong-Brender, Thanh Thi Kim ; Labouesse, Michel ; Laboratoire de Physique Statistique de l'ENS (LPS) ; Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS) ; École normale supérieure - Paris (ENS Paris) ; Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris) ; Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) ; Institut Universitaire de Cancérologie Paris (IUC) ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS) ; Laboratoire de Biologie du Développement Paris (LBD) ; Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS) ; Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
Link: | |
Zeitschrift: | ISSN: 0031-9007, 2018 |
Veröffentlichung: | HAL CCSD ; American Physical Society, 2018 |
Medientyp: | academicJournal |
ISSN: | 0031-9007 |
DOI: | 10.1103/PhysRevLett.121.268102 |
Schlagwort: |
|
Sonstiges: |
|