Synthesis and Antimicrobial Activity of Bisphosphonates
In: Journal of Chemical Research, Jg. 2009 (2009), Heft 4, S. 258-260
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Zugriff:
Dimethyl [(substitutedphenyl)(6-oxo6λ 5 dibenzo[ d,f][1,3,2]dioxaphophepin-6-yl)methyl]phosphonates (5a-j) were synthesised through a three step process involving preparation of dimethyl hydroxy(substitutedphenyl)methyl-phosphonates (4a-j) and their reaction with 6-bromodibenzo[ d,f][1,3,2]dioxaphosphepine (2) in dry toluene in the presence of triethylamine at 50–60°C. Tetramethylguanidine (TMG) as a catalyst was found to increase the yields and purity of the products. These compounds were characterised by IR, 1 H, 13 C, 31 P NMR and mass spectral data found to possess higher antimicrobial activity then the standards.
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Synthesis and Antimicrobial Activity of Bisphosphonates
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Autor/in / Beteiligte Person: | Reddy, M. Veera Narayana ; Reddy, K.R. Kishore Kumar ; Reddy, C. Bhupendra ; Kumar, B. Siva ; Reddy, C. Suresh ; Reddy, C. Devendranath |
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Zeitschrift: | Journal of Chemical Research, Jg. 2009 (2009), Heft 4, S. 258-260 |
Veröffentlichung: | SAGE Publications, 2009 |
Medientyp: | academicJournal |
ISSN: | 1747-5198 |
DOI: | 10.3184/030823409x439744 |
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