Analysis of Volatile Organic Compounds in Exhaled Air in Patients with Sickle Cell Disease during Vaso-Occlusive Episodes
In: Blood, Jg. 142 (2023-11-28), Heft 1, Number 1 Supplement 1, S. 1131
serialPeriodical
Zugriff:
Background:Sickle cell disease (SCD) is an inherited red blood cell disorder characterized by hemolytic anemia, inflammation and vaso-occlusion. Due to the process of vaso-occlusion patients with SCD experience unpredictable and painful vaso-occlusive episodes (VOE), causing stress and disruption of daily life. To date, we lack adequate markers to predict the development of a VOE before it occurs. In other conditions such as asthma, exhaled air analyses have shown to be of diagnostic value and may predict exacerbations. In the human body, metabolic processes generate volatile organic compounds, that are first released into the blood, and then exhaled by the lungs. As a result, exhaled air consists of several volatile, organic compounds that may reflect pathophysiological disease processes. As we presently lack urgently needed biomarkers to predict VOEs, the aim of this study was to identify distinctive volatile organic compounds in exhaled air (eVOC) during VOE in patients with SCD, that may serve as predictors of VOE when detected in low quantities as a VOE is evolving.
Titel: |
Analysis of Volatile Organic Compounds in Exhaled Air in Patients with Sickle Cell Disease during Vaso-Occlusive Episodes
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Autor/in / Beteiligte Person: | Vuong, Caroline ; Brinkman, Paul ; Heijboer, Harriët ; Nur, Erfan ; De Groot - Eckhardt, Cornelia ; Terheggen-Lagro, Suzanne W.J. ; Biemond, Bart J. ; Maitland-van der Zee, Anke-Hilse ; Fijnvandraat, Karin |
Zeitschrift: | Blood, Jg. 142 (2023-11-28), Heft 1, Number 1 Supplement 1, S. 1131 |
Veröffentlichung: | 2023 |
Medientyp: | serialPeriodical |
ISSN: | 0006-4971 (print) ; 1528-0020 (print) |
DOI: | 10.1182/blood-2023-180835 |
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