Intrathymic AAV delivery results in therapeutic site-specific integration at TCR loci in mice
In: Blood, Jg. 141 (2023-05-11), Heft 19, S. 2316-2329
serialPeriodical
Zugriff:
•Intrathymic delivery of AAV results in vector integration within TCR genes at RAG-induced DNA breaks produced during V(D)J recombination.•This “targeting” approach opens therapeutic avenues for long-term AAV gene transfer in dividing cells without any toxic conditioning.
Titel: |
Intrathymic AAV delivery results in therapeutic site-specific integration at TCR loci in mice
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Autor/in / Beteiligte Person: | Calabria, Andrea ; Cipriani, Carlo ; Spinozzi, Giulio ; Rudilosso, Laura ; Esposito, Simona ; Benedicenti, Fabrizio ; Albertini, Alessandra ; Pouzolles, Marie ; Luoni, Mirko ; Giannelli, Serena ; Broccoli, Vania ; Guilbaud, Mickael ; Adjali, Oumeya ; Taylor, Naomi ; Zimmermann, Valérie S. ; Montini, Eugenio ; Cesana, Daniela |
Zeitschrift: | Blood, Jg. 141 (2023-05-11), Heft 19, S. 2316-2329 |
Veröffentlichung: | 2023 |
Medientyp: | serialPeriodical |
ISSN: | 0006-4971 (print) ; 1528-0020 (print) |
DOI: | 10.1182/blood.2022017378 |
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