Cabotegravir for the prevention of HIV-1 in women: results from HPTN 084, a phase 3, randomised clinical trial
In: The Lancet, Jg. 399 (2022-05-07), Heft 10337, S. 1779-1789
Online
serialPeriodical
Zugriff:
Oral pre-exposure prophylaxis has been introduced in more than 70 countries, including many in sub-Saharan Africa, but women experience considerable barriers to daily pill-taking, such as stigma, judgement, and the fear of violence. Safe and effective long-acting agents for HIV prevention are needed for women. We aimed to evaluate the safety and efficacy of injectable cabotegravir compared with daily oral tenofovir diphosphate plus emtricitabine (TDF-FTC) for HIV prevention in HIV-uninfected women.
Titel: |
Cabotegravir for the prevention of HIV-1 in women: results from HPTN 084, a phase 3, randomised clinical trial
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Autor/in / Beteiligte Person: | Delany-Moretlwe, Sinead ; Hughes, James P ; Bock, Peter ; Ouma, Samuel Gurrion ; Hunidzarira, Portia ; Kalonji, Dishiki ; Kayange, Noel ; Makhema, Joseph ; Mandima, Patricia ; Mathew, Carrie ; Spooner, Elizabeth ; Mpendo, Juliet ; Mukwekwerere, Pamela ; Mgodi, Nyaradzo ; Ntege, Patricia Nahirya ; Nair, Gonasagrie ; Nakabiito, Clemensia ; Nuwagaba-Biribonwoha, Harriet ; Panchia, Ravindre ; Singh, Nishanta ; Siziba, Bekezela ; Farrior, Jennifer ; Rose, Scott ; Anderson, Peter L ; Eshleman, Susan H ; Marzinke, Mark A ; Hendrix, Craig W ; Beigel-Orme, Stephanie ; Hosek, Sybil ; Tolley, Elizabeth ; Sista, Nirupama ; Adeyeye, Adeola ; Rooney, James F ; Rinehart, Alex ; Spreen, William R ; Smith, Kimberly ; Hanscom, Brett ; Cohen, Myron S ; Hosseinipour, Mina C ; Asmelash, Aida ; Sehurutshi, Alice ; Baguma, Allan ; Marais, Anita ; Kawoozo, Barbarah ; Malinga, Bongiwe Prudence ; Mirembe, Brenda Gati ; Okech, Brenda ; Esterhuizen, Bryan ; Murombedzi, Caroline ; Gadama, Daphne ; Hwengwere, Eldinah ; Roos, Elizabeth ; Magada, Elizabeth S ; Shava, Emily ; Piwowar-Manning, Estelle ; Tahuringana, Eunice ; Muhlanga, Felix GS ; Conradie, Francesca ; Angira, Frank ; Nanyonjo, Gertrude ; Kistnasami, Girisha ; Mvula, Hazzie ; Naidoo, Ishana ; Horak, Jaco ; Jere, Jane ; Moodley, Jeeva ; Shin, Katie ; Nel, Kerry ; Bokoch, Kevin ; Birungi, Lilian ; Emel, Lynda ; Monametsi, Maletsatsi ; Sibanda, Marvelous ; Mutambanengwe, Mercy ; Chitukuta, Miria ; Matimbira, Moleen ; Bhondai-Mhuri, Muchaneta ; Sibisi, Ncamsile ; Morar, Neetha ; Mudzonga, Netsai ; Natureeba, Paul ; Richardson, Paul ; Musara, Petina ; Macdonald, Pippa ; Nkambule, Rejoice ; Mosime, Repelang ; White, Rhonda ; Berhanu, Ribka ; Ncube-Sihlongonyane, Ritha ; Sekabira, Rogers ; Siva, Samantha ; Pillay, Saresha ; Govender, Shamelle ; Bamweyana, Sheiala ; Nzimande, Siyabonga ; Innes, Steve ; Dadabhai, Sufia ; Samandari, Taraz ; Tembo, Tchangani ; Lungu Mabedi, Thandie ; Chirenda, Thandiwe ; Chidemo, Tinashe ; Mudhune, Victor ; Naidoo, Vikesh ; Samaneka, Wadzanai ; Agyei, Yaw ; Musodza, Yeukai ; Fourie, Yolandie ; Gaffoor, Zakir |
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Zeitschrift: | The Lancet, Jg. 399 (2022-05-07), Heft 10337, S. 1779-1789 |
Veröffentlichung: | 2022 |
Medientyp: | serialPeriodical |
ISSN: | 0140-6736 (print) ; 1474-547X (print) |
DOI: | 10.1016/S0140-6736(22)00538-4 |
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