Pediatric-inspired intensified therapy of adult T-ALL reveals the favorable outcome of NOTCH1/FBXW7mutations, but not of low ERG/BAALCexpression: a GRAALL study
In: Blood, Jg. 118 (2011-11-10), Heft 19, S. 5099-5107
serialPeriodical
Zugriff:
Despite recent progress in the understanding of acute lymphoblastic leukemia (T-ALL) oncogenesis, few markers are sufficiently frequent in large subgroups to allow their use in therapeutic stratification. Low ERGand BAALCexpression (E/Blow) and NOTCH1/FBXW7 (N/F) mutations have been proposed as powerful prognostic markers in large cohorts of adult T-ALL. We therefore compared the predictive prognostic value of N/Fmutations versus E/Blowin 232 adult T-ALLs enrolled in the LALA-94 and Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) protocols. The outcome of T-ALLs treated in the pediatric-inspired GRAALL trials was significantly superior to the LALA-94 trial. Overall, 43% and 69% of adult T-ALL patients were classified as E/Blowand N/Fmutated, respectively. Strikingly, the good prognosis of N/Fmutated patients was stronger in more intensively treated, pediatric-inspired GRAALL patients. The E/Bexpression level did not influence the prognosis in any subgroup. N/Fmutation status and the GRAALL trial were the only 2 independent factors that correlated with longer overall survival by multivariate analysis. This study demonstrates that the N/Fmutational status and treatment protocol are major outcome determinants for adults with T-ALL, the benefit of pediatric inspired protocols being essentially restricted to the N/Fmutated subgroup.
Titel: |
Pediatric-inspired intensified therapy of adult T-ALL reveals the favorable outcome of NOTCH1/FBXW7mutations, but not of low ERG/BAALCexpression: a GRAALL study
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Autor/in / Beteiligte Person: | Ben Abdelali, Raouf ; Asnafi, Vahid ; Leguay, Thibaut ; Boissel, Nicolas ; Buzyn, Agnès ; Chevallier, Patrice ; Thomas, Xavier ; Lepretre, Stephane ; Huguet, Françoise ; Vey, Norbert ; Escoffre-Barbe, Martine ; Tavernier, Emmanuelle ; Reman, Oumedaly ; Fegueux, Nathalie ; Turlure, Pascal ; Rousselot, Philippe ; Cahn, Jean-Yves ; Lheritier, Veronique ; Chalandon, Yves ; Béné, Marie-Christine ; Macintyre, Elizabeth ; Dombret, Hervé ; Ifrah, Norbert |
Zeitschrift: | Blood, Jg. 118 (2011-11-10), Heft 19, S. 5099-5107 |
Veröffentlichung: | 2011 |
Medientyp: | serialPeriodical |
ISSN: | 0006-4971 (print) ; 1528-0020 (print) |
DOI: | 10.1182/blood-2011-02-334219 |
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