Interaction of Valproic Acid and Amitriptyline
In: Journal of Clinical Psychopharmacology, Jg. 33 (2013-08-01), Heft 4, S. 561-564
Online
serialPeriodical
Zugriff:
Amitriptyline (AMI) and valproic acid (VPA) are common psychotropic drugs which are frequently used in psychiatry and also administered in neurology or anesthesia in the absence of a psychiatric indication. On the basis of the case of a 73-year-old man with therapy-resistant major depressive episode who experienced anticholinergic delirium after adding VPA to AMI, we retrospectively analyzed therapeutic drug monitoring data of the years 2008 to 2010. We assessed cases receiving a combination of AMI and VPA, and obtained a control sample of AMI patients without VPA which were matched for sex, age, daily dose, and comedication. Both samples were compared regarding the serum levels of AMI and nortriptyline (NOR) as well as the ratio of NOR and AMI with the Mann-Whitney Utest. The combination of AMI and VPA led to a remarkable increase of AMI and NOR serum levels. When comparing 33 patients who received comedication with VPA versus 33 matched controls, the total concentration by combining mean AMI and NOR serum levels (237.1 119.9 vs 126.4 52.8 ngmL) and NORAMI ratio (1.300 0.905 vs 0.865 0.455) was significantly higher.
Titel: |
Interaction of Valproic Acid and Amitriptyline
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Autor/in / Beteiligte Person: | Unterecker, Stefan ; Burger, Rainer ; Hohage, Amelie ; Deckert, Jürgen ; Pfuhlmann, Bruno |
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Zeitschrift: | Journal of Clinical Psychopharmacology, Jg. 33 (2013-08-01), Heft 4, S. 561-564 |
Veröffentlichung: | 2013 |
Medientyp: | serialPeriodical |
ISSN: | 0271-0749 (print) ; 1533-712X (print) |
DOI: | 10.1097/JCP.0b013e3182905d42 |
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