The mouse col11a2 gene. Some transcripts from the adjacent rxr-β gene extend into the col11a2 gene
In: Matrix Biology, Jg. 15 (1996), Heft 5, S. 359-367
Online
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Zugriff:
Type XI collagen is present in small amounts in cartilage, together with small amounts of type IX and type V collagens and large amounts of type II collagen. Here, primers based on the nucleotide sequences of partial human cDNAs and mouse genomic DNAs that were analyzed by other investigators were used to isolate a cDNA for the mouse of col11a2 gene. Cosmid clones for the mouse col11a2 gene were isolated, and 12.4 kb of the nucleotide sequences were defined. Analysis of the genomic sequences identified three exons in the mouse gene that were recently shown to undergo alternative splicing (Tsumaki and Kimura, J. Biol. Chem. 270, 2372-2378, 1995; Zhidkova et al., J. Biol. Chem. , 270, 94886-9493, 1995). In addition, analysis of the cosmid clones revealed tht the 5′ end of the mouse col11a2 gene was located head-to-tail with the mouse retinoic X receptor β gene, RT-PCR assays demonstrated that some transcripts from the retinoic X receptor β gene extend into the col11a2 gene. Therefore, there may be coordinate expression of the two genes.
Titel: |
The mouse col11a2 gene. Some transcripts from the adjacent rxr-β gene extend into the col11a2 gene
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Autor/in / Beteiligte Person: | Vandenberg, Philipp ; Vuoristo, Mirka M. ; Ala-Kokko, Leena ; Prockop, Darwin J. |
Link: | |
Zeitschrift: | Matrix Biology, Jg. 15 (1996), Heft 5, S. 359-367 |
Veröffentlichung: | 1996 |
Medientyp: | serialPeriodical |
ISSN: | 0945-053X (print) |
DOI: | 10.1016/S0945-053X(96)90139-0 |
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