Apoptotic effects and glucose-6-phosphate dehydrogenase responses in liver and gill tissues of rainbow trout treated with chlorpyrifos.
In: Tissue & Cell, Jg. 46 (2014-12-01), Heft 6, S. 490-496
Online
academicJournal
Zugriff:
We investigated apoptotic effects and changes in glucose-6-phosphate dehydrogenase (G6PD) enzyme activity in liver and gill tissues of fish exposed to chlorpyrifos. Three different chlorpyrifos doses (2.25, 4.5 and 6.75 μg/L) were administrated to rainbow trout at different time intervals (24, 48, 72 and 96 h). Acute exposure to chlorpyrifos showed time dependent decrease in G6PD enzyme activity at all concentrations ( p < 0.05). Immunohistochemical results showed that chlorpyrifos caused mucous cell loss in gill tissue and apoptosis via caspase-3 activation in fish. The present study suggested that chlorpyrifos inhibits G6PD enzyme and causes mucous cell loss in gill and apoptosis in gill and liver tissues. [ABSTRACT FROM AUTHOR]
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Apoptotic effects and glucose-6-phosphate dehydrogenase responses in liver and gill tissues of rainbow trout treated with chlorpyrifos.
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Autor/in / Beteiligte Person: | Topal, Ahmet ; Atamanalp, Muhammed ; Oruç, Ertan ; Kırıcı, Muammer ; Kocaman, Esat Mahmut |
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Zeitschrift: | Tissue & Cell, Jg. 46 (2014-12-01), Heft 6, S. 490-496 |
Veröffentlichung: | 2014 |
Medientyp: | academicJournal |
ISSN: | 0040-8166 (print) |
DOI: | 10.1016/j.tice.2014.09.001 |
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