Funkcija T limfocita laringektomisanih bolesnika. (Croatian)
In: Acta Chirurgica Iugoslavica, Jg. 58 (2011-03-01), Heft 1, S. 67-72
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Zugriff:
Aim: Malignant tumors of the larynx account for 2.3% of all malignancies, while their frequency among tumors of the head and neck ranges between 12% and 20%. Research on the general immune competence in patients with malignant diseases has provided useful insight in the relationship between immune disorders on one side and the clinical course on the other. Unfortunately, only few complete studies have been published so far with this regard in patients with malignant tumors of the larynx, and therefore our study was essentially aimed at establishing of general immunocompetence, presence and levels of the possible immune disorders and their association with the malignant tumors. Material and method: The study included forty two patients with primary squamocellular laryngeal cancer. All the patients underwent surgery, out of whom fifteen were treated postoperatively with radiotherapy. We tested the immune competence prior to the operation and in the postoperative period nine months later. In the venous blood we examined T lymphocyte function, monocyte levels and mononuclear phagocyte function. Results: Preoperative evaluation of the presence and levels of general immune competence in patients with laryngeal cancer, showed a distinct decrease in the proliferative response to the PHA mitogen in vitro, with a tendency to normalize in patients who do not develop a relapse of the disease or distant metastasis during the follow-up period. During the whole study period, the number of monocytes and mononuclear phagocyte activity was above the normal level. Conclusion: The patients with operable laryngeal carcinoma had considerable immune disorders at various levels, primarily at the level ofT lymphocytes. Of all the disorders, reduced mitotic activity of T lymphocytes in response to mitogens showed the highest dependance on the presence of malignant tissue in the organism [ABSTRACT FROM AUTHOR]
Cilj: Maligni tumori larinksa u grupi svih malignih bolesti zastupljeni su sa 2,3%, a učestalost medju tumorima glave i vrata je od 12 do 20%. Istraživanja op šte imunološke kompetencije u bolesnika sa malignim oboljenjima su obezbedila korisne informacije o odnosima izmedju imunolo ških poremećaja sa jedne strane i klini čkog toka, sa druge. U obolelih sa malignim tumorima larinksa d sada su u tom smislu obavljena malobrojna i nepotp na istraživanja, stoga smo kao osnovni cilj u radu po tavili da se u bolesnika sa operabilnim karcinomom la rinksa i pre i posle terapije utvrdi op šta imunoloćk kompetencija i prisustvo i nivoi eventualnih imuno loških poremećaja i njihova povezanost sa malignim tumorom. Materijal i metod: lspitivana su 42 bolesnika sa pri marnim planocelularnim karcinomom larinksa, u Kli nici za otorinolaringologiju i maksilofacijalnu hirurgiju u Beogradu. Svi bolesnici su le čeni hirur ški i u 15 bolesnika je sprovedena i postoperativna radi terapija. U venskoj krvi odredjivani su: funkcija ćelija, broji fagocitna aktivnost monocita, pre operat vno i u etapama devet meseci postoperativno. Poseb kontrolnu grupu činili su bolesnici sa benignim izra štajima larinksa i zdravi dobrovoljni davaoci krvi. Rezultati: Odredjivanjem prisustva i nivoa op šte im nolo ške kompetencije u bolesnika sa karcinomom la rinksa pre operacije nadjeno je izrazito smanjenj proliferativnog odgovora na PHA mitogen in vitro s tendencijom normalizacije u bolesnika koji ne razvija ju recidive i metastaze u čitavom periodu praćenj Broj monocita i fagocitna aktivnost se odr žavaju izna normale u čitavom toku ispitivanja. Zaklju čak: U pacijenata sa operabilnim karcinomom larinksa prisutni su zna čajni imunolo ški poremećaji na raznim nivoima, ali pre svega na nivou T limfocit Od svih ovih poremećaja, smanjena mitotska akti nost T limfocita u odgovoru na mitogene pokazala najveći stepen zavisnosti od prisustva u organizmu malignog tkiva. [ABSTRACT FROM AUTHOR]
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Titel: |
Funkcija T limfocita laringektomisanih bolesnika. (Croatian)
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Autor/in / Beteiligte Person: | Dimitrijević, Milovan V. ; Dudvarski, Zoran R. ; Vučićević, Slavko S. ; Nešić, Vladimir S. ; Pavlović, Bojan M. |
Zeitschrift: | Acta Chirurgica Iugoslavica, Jg. 58 (2011-03-01), Heft 1, S. 67-72 |
Veröffentlichung: | 2011 |
Medientyp: | academicJournal |
ISSN: | 0354-950X (print) |
DOI: | 10.2298/ACI1101067D |
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