Effects of tibolone and continuous combined hormone replacement therapy on mammographic breast density.
In: American Journal of Obstetrics & Gynecology, Jg. 186 (2002-04-01), Heft 4, S. 717-722
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Zugriff:
Objective: Our purpose was to compare the effects of tibolone, continuous combined hormone replacement therapy, and placebo on mammographic breast density. Study Design: A prospective, randomized, double-blind placebo-controlled study was performed. A total of 166 postmenopausal women were equally randomized to receive tibolone 2.5 mg, estradiol 2 mg/norethisterone acetate 1 mg (E(2)/NETA), or placebo. Mammograms were performed at baseline and after 6 months of treatment. Mammographic density was quantified according to the Wolfe classification and by the percentage area of the breast that had a dense pattern. Results: An increase in mammographic density was much more common among women receiving continuous combined hormone replacement therapy (46%-50%) than among those receiving tibolone (2%-6%) and placebo (0%) treatment. The difference between E(2)/NETA and placebo was highly significant (P <.001). Treatment with tibolone did not differ from that with placebo. The relative risk of an increase in breast density for E(2)/NETA versus tibolone was found to be 8.3 (95% CI 2.7-25.0). Conclusion: An increase in mammographic density should be regarded as an unwanted side effect of hormone replacement therapy. In contrast to estrogen/progestogen treatment, tibolone seems to exert little stimulation of breast tissue. [ABSTRACT FROM AUTHOR]
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Titel: |
Effects of tibolone and continuous combined hormone replacement therapy on mammographic breast density.
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Autor/in / Beteiligte Person: | Lundstr&oum;m, Eva ; Christow, Alexander ; Kersemaekers, Wendy ; Svane, Gunilla ; Azavedo, Edward ; Söderqvist, Gunnar ; Mol-Arts, Mirjam ; Barkfeldt, Jan ; von Shoultz, Bo ; Lundström, Eva ; von Schoultz, Bo |
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Zeitschrift: | American Journal of Obstetrics & Gynecology, Jg. 186 (2002-04-01), Heft 4, S. 717-722 |
Veröffentlichung: | 2002 |
Medientyp: | academicJournal |
ISSN: | 0002-9378 (print) |
DOI: | 10.1067/mob.2002.121896 |
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