Profils western-blot et stades cliniques chez les patients séropositifs au VIH au Maroc. (French)
In: Revue Francophone des Laboratoires, Jg. 2009 (2009-11-02), Heft 416, S. 19-22
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Zugriff:
Summary: Aim: to analyse western-blot HIV profiles and assess their association with clinical stages in a Moroccan HIV-1 infected population. Material and methods: We performed a retrospective study about 124 of patients for whom the HIV infection diagnosis has been confirmed by a western-blot technique (HIV BLOT 2.2, MP Diagnostics). We used WHO (World Health Organisation) criterion to interpret the WB profiles. Results: We observed an overall band pattern including GP160, GP120, P66, P55, P51, GP41, P39, P31, P24 and P17 proteins in 80% of cases (99/124). Among all WB patterns, P17 band was lacking in 12% (15/124) of cases versus 6,4% (8/124) for P66, P55 and P39 respectively, and 4,8% (6/124) for P51 and 3,2% (4/124) for P31 bands. Related to the clinical stages of patients according to CDC 93 (Center for disease control) classification, we noticed that 79% (19/24) of category A, 82% (18/22) of category B and 79,5% (62/78) of category C had an overall band pattern. Compared to other clinical categories, we reported various incomplete patterns among the patients of group C: P17 was lacking in 11 of 16 cases, followed by P66 (8 cases), P55, P51 and P39 (5 cases), P31 (2 cases) and P24 (1 case), whereas, few bands were lacking among both A and B categories profiles. P17 was the only missing band in 4 of 5 incomplete patterns among category A. P39 and P55 bands were the most lacking (3/4 cases) in category B. We also described only one indeterminate profile in category A. Conclusion: The Interpretation of WB band patterns in considering clinical stages may be used as an occasional tool to predicting the status of HIV infection. Nevertheless, a good and objective association requires the combination of the immune status of patients. [Copyright &y& Elsevier]
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Profils western-blot et stades cliniques chez les patients séropositifs au VIH au Maroc. (French)
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Autor/in / Beteiligte Person: | Admou, Brahim ; Zougaghi, Laila ; Soraa, Nabila ; Amine, Mohamed ; Tassi, Nora ; Kachach, Mostapha ; Aajly, Lahcen ; Hajji, Abdelmajid ; Fajali, Noura ; El Harti, Elmir ; Oumzil, Hicham ; Bennani, Ouafaa ; Mengad, Rajae ; Siwani, Amina ; Belbacha, Imane ; El Aouad, Rajae ; Chabaa, Laila |
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Zeitschrift: | Revue Francophone des Laboratoires, Jg. 2009 (2009-11-02), Heft 416, S. 19-22 |
Veröffentlichung: | 2009 |
Medientyp: | academicJournal |
ISSN: | 1773-035X (print) |
DOI: | 10.1016/S1773-035X(09)70270-9 |
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