Influence of Psychosocial Work-Related Factors on Conventional Risk Factors of Ischemic Heart Disease and Homocysteine in Slovenian Male Workers.

The influence of psychosocial work-related factors on the conventional risk factors of ischemic heart disease (IHD), particularly on the lipid changes and their effect on homocysteine is studied in this paper. Employed males aged 35 to 55 with angina pectoris or a myocardial infarction (IHD group) were compared to a group of individuals without ischemic heart disease (Control Group). Psychosocial factors were assessed using a Swedish Theorell questionnaire. The IHD Group was found to be at a higher risk of IHD due to higher work demands (OR = 1.25), worse job control (OR = 1.23), frequent smoking (OR = 2.2), leadership positions (OR = 3.97), higher BMI (p = 0.059) and higher levels of triglycerides (p = 0.005) and LDL-cholesterol (OR = 1.65). The level of HDL-cholesterol was significantly lower (1.0 vs. 1.4 mmol/L, p < 0.001, OR = 1,64), while the level of C-reactive protein (9.1 vs. 1.8 mg/L) and Interleukin-6 (6.5 vs. 1.6 ng/L) was higher. Homocysteine levels showed borderline significance (p = 0.056). Our study suggests a possible influence of psychosocial work-related factors on IHD risk factors, most of all on low HDL-cholesterol. No connection was found between psychosocial factors and the homocysteine level, shown to be an IHD risk factor at lower levels of approximately 10 µmol/L. [ABSTRACT FROM AUTHOR]

U ovom se radu proučava utjecaj psihosocijalnih, s radom povezanih, čimbenika na uobičajene rizične čimbenike ishemijskih bolesti srca (IHD), posebice na promjene lipida i njihov učinak na homocistein. Zaposleni muškarci u dobi od 35 do 55 godina s anginom pectoris ili s infarktom miokarda (IHD skupina) uspoređeni su sa skupinom pojedinaca bez ishemične bolesti srca (kontrolna skupina). Psihosocijalni čimbenici procijenjeni su korištenjem švedskog Theorell upitnika. Ustanovljeno je da IHD skupina ima veći rizik od IHD-a zbog većih zahtjeva na poslu (OR = 1,25), lošije kontrole posla (OR = 1,23), čestog pušenja (OR = 2,2), vodećih pozicija (OR = 3,97), većeg indeksa tjelesne mase (BMI) (p = 0,059) i višeg nivo triglicerida (P = 0,005) i LDL-kolesterola (OR = 1,65). Razina HDL-kolesterola bita je značajno niža (1,0 vs. 1.4 mmol/L, p < 0,001, OR = 1,64), dok je razina C-reaktivnog proteina (9,1 vs. 1,8 mg/L) i interleukina-6 (6,5 vs. 1,6 ng/L) bila viša. Razine homocisteina su pokazale graničnu vrijednost (p = 0,056). Naša studija ukazuje na mogući utjecaj psihosocijalnih čimbenika povezanih s radom na rizik od ishemijskih bolesti srca (IHD), ponajviše na nizak HDL-kolesterol. Nije pronađena veza između psihosocijalnih čimbenika i razina homocisteina, za koji se pokazalo da je IHD rizični čimbenik na nižim razinama od otprilike 10 µmol/L. [ABSTRACT FROM AUTHOR]

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