Using a Förster-resonance energy transfer (FRET)-based detection system (FedEcs) to monitor nanoparticle cargo delivery to the brain (Updated February 29, 2024).
In: Genomics & Genetics Weekly, 2024-03-22, S. 2472
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A preprint abstract from biorxiv.org discusses the use of nanotechnology to improve drug delivery to the brain. The researchers developed fluorescent lipid nanodroplets (LNDs) that carry a drug delivery detection system called FedEcs, which can monitor cargo release in vivo. Through intravital multiphoton microscopy, they observed that the LNDs accumulated in cerebral microclots after ischemia and released their cargo. The study also found that the blood-brain barrier became permeable at sites of microclots, allowing the LNDs to cross and deliver their cargo to the brain parenchyma. This research provides a new tool for investigating the biodistribution and cargo release of nanocarriers using intravital microscopy. [Extracted from the article]
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Using a Förster-resonance energy transfer (FRET)-based detection system (FedEcs) to monitor nanoparticle cargo delivery to the brain (Updated February 29, 2024).
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Zeitschrift: | Genomics & Genetics Weekly, 2024-03-22, S. 2472 |
Veröffentlichung: | 2024 |
Medientyp: | serialPeriodical |
ISSN: | 1531-6467 (print) |
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