Resveratrol prevents oxidative damage and loss of sperm motility induced by long-term treatment with valproic acid in Wistar rats.
In: Experimental & Toxicologic Pathology, Jg. 68 (2016-09-01), Heft 8, S. 435-443
Online
academicJournal
Zugriff:
Valproic acid (VPA) is a drug widely use for the treatment of epilepsy in both children and adults. Evidence suggests that long-term use of VPA may lead to an impairment in the male reproductive function. Oxidative stress is considered to play a major role in VPA associated toxicity. In the present work, we demonstrated that the natural antioxidant compound resveratrol (RSV) can be use to prevent VPA oxidative damage. Wistar rats treated with VPA (400 mg kg −1 ) by gavage for 28 days showed decrease in sperm motility accompanied by increase in oxidative damage to lipids and proteins. Additionally, VPA administration leaded to depletion of reduced glutathione and decrease in total antioxidant potential in testes and epididymides of Wistar rats. The co-administration of RSV (10 mg kg −1 ) efficiently prevented VPA pro-oxidant effects. In summary, RSV was shown to protect the reproductive system from the damage induced by VPA. Altogether, our data strongly suggests that RSV administration might be a valuable strategy to minimize reproductive impairment in patients requiring long-term VPA treatment. [ABSTRACT FROM AUTHOR]
Copyright of Experimental & Toxicologic Pathology is the property of Urban & Fischer Verlag and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Resveratrol prevents oxidative damage and loss of sperm motility induced by long-term treatment with valproic acid in Wistar rats.
|
---|---|
Autor/in / Beteiligte Person: | Ourique, Giovana M. ; Pês, Tanise S. ; Saccol, Etiane M.H. ; Finamor, Isabela A. ; Glanzner, Werner G. ; Baldisserotto, Bernardo ; Pavanato, Maria A. ; Gonçalves, Paulo B.D. ; Barreto, Kátia P. |
Link: | |
Zeitschrift: | Experimental & Toxicologic Pathology, Jg. 68 (2016-09-01), Heft 8, S. 435-443 |
Veröffentlichung: | 2016 |
Medientyp: | academicJournal |
ISSN: | 0940-2993 (print) |
DOI: | 10.1016/j.etp.2016.07.001 |
Schlagwort: |
|
Sonstiges: |
|