From Chitin to Bioactive Chitooligosaccharides and Conjugates: Access to Lipochitooligosaccharides and the TMG-chitotriomycin.
In: Angewandte Chemie, Jg. 126 (2014-10-27), Heft 44, S. 12106-12110
Online
academicJournal
Zugriff:
The direct and chemoselective N-transacylation of peracetylated chitooligosaccharides (COSs), readily obtained from chitin, to give per- N-trifluoroacetyl derivatives offers an attractive route to size-defined COSs and derived glycoconjugates. It involves the use of various acceptor building blocks and trifluoromethyl oxazoline dimer donors prepared with efficiency and highly reactive in 1,2- trans glycosylation reactions. This method was applied to the preparation of the important symbiotic glycolipids which are highly active on plants and to the TMG-chitotriomycin, a potent and specific inhibitor of insect, fungal, and bacterial N-acetylglucosaminidases. [ABSTRACT FROM AUTHOR]
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From Chitin to Bioactive Chitooligosaccharides and Conjugates: Access to Lipochitooligosaccharides and the TMG-chitotriomycin.
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Autor/in / Beteiligte Person: | Despras, Guillaume ; Alix, Aurélien ; Urban, Dominique ; Vauzeilles, Boris ; Beau, Jean ‐ Marie |
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Zeitschrift: | Angewandte Chemie, Jg. 126 (2014-10-27), Heft 44, S. 12106-12110 |
Veröffentlichung: | 2014 |
Medientyp: | academicJournal |
ISSN: | 0044-8249 (print) |
DOI: | 10.1002/ange.201406802 |
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