Carboxylic acid-catalyzed one-pot synthesis of cyanoacetylureas and their cyclization to 6-aminouracils in guanidine ionic liquid.
In: Chemical Monthly / Monatshefte für Chemie, Jg. 144 (2013-03-01), Heft 3, S. 399-403
Online
academicJournal
Zugriff:
A novel, one-pot, carboxylic acid-catalyzed synthesis of cyanoacetylureas via in situ generated ureas and their cyclization to 6-aminouracils in the presence of the guanidine-based ionic liquid 1,1,3,3-tetramethylguanidine lactate [TMG][Lac] is described. The ureas were synthesized from amines and potassium cyanate, which on reaction with cyanoacetic acid in the presence of acetic anhydride in the same pot afforded cyanoacetylureas, which undergo cyclization in [TMG][Lac] as solvent as well as catalyst to afford 6-aminouracils. One-pot synthesis of cyanoacetylureas, efficient and rapid cyclization, better yield, shorter reaction time, easy workup procedure, and recyclability of the ionic liquid are some advantages of this procedure. Graphical abstract: [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]
Copyright of Chemical Monthly / Monatshefte für Chemie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Carboxylic acid-catalyzed one-pot synthesis of cyanoacetylureas and their cyclization to 6-aminouracils in guanidine ionic liquid.
|
---|---|
Autor/in / Beteiligte Person: | Chavan, Sunil ; Shelke, Rupesh ; Degani, Mariam |
Link: | |
Zeitschrift: | Chemical Monthly / Monatshefte für Chemie, Jg. 144 (2013-03-01), Heft 3, S. 399-403 |
Veröffentlichung: | 2013 |
Medientyp: | academicJournal |
ISSN: | 0026-9247 (print) |
DOI: | 10.1007/s00706-012-0810-9 |
Sonstiges: |
|