The prognostic capacity of B-type natriuretic peptide on cognitive disorder varies by age.
In: Annals of Medicine, Jg. 45 (2013-02-01), Heft 1, S. 74-78
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Zugriff:
Introduction. It is known that blood levels of natriuretic peptides associate with cognitive disorder among the middle-aged. We aimed to test whether this association is valid in an older population aged 75 years or older. Methods. A total of 601 older subjects aged 75 or older participated in the study. A subgroup of 137 with a diagnosed cognitive disorder were tested for natriuretic peptides (ANP, NT-proANP, and BNP), and compared with age-matched controls ( n = 464). The control group was followed-up for 5 years, and the association of the baseline BNP with the occurrence of cognitive impairment was studied. Results. In the youngest age tertile (75-78 y), BNP was significantly associated with a diagnosed cognitive disorder when other factors with a known effect on natriuretic peptides were taken into account. In the oldest tertile (83-96 y), higher BNP values suggested the absence of cognitive dysfunction. ANP and NT-proANP did not associate with the presence of cognitive impairment. Among the control group, BNP predicted a cognitive disorder at follow-up, but only in the youngest tertile. Conclusions. The previously found link between a high BNP concentration and cognitive disorder in older people is only valid among those aged less than 79 years. [ABSTRACT FROM AUTHOR]
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Titel: |
The prognostic capacity of B-type natriuretic peptide on cognitive disorder varies by age.
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Autor/in / Beteiligte Person: | Hiltunen, Matti ; Kerola, Tuomas ; Kettunen, Raimo ; Hartikainen, Sirpa ; Sulkava, Raimo ; Vuolteenaho, Olli ; Nieminen, Tuomo |
Zeitschrift: | Annals of Medicine, Jg. 45 (2013-02-01), Heft 1, S. 74-78 |
Veröffentlichung: | 2013 |
Medientyp: | academicJournal |
ISSN: | 0785-3890 (print) |
DOI: | 10.3109/07853890.2012.663929 |
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