Study of a Localized Meningococcal Meningitis Epidemic in Burkina Faso: Incidence, Carriage, and Immunity.
In: Journal of Infectious Diseases, Jg. 204 (2011-12-01), Heft 11, S. 1787-1795
Online
academicJournal
Zugriff:
Background. To better understand localized meningococcal meningitis epidemics, we evaluated a serogroup A (NmA) epidemic in Burkina Faso by surveillance, carriage, and seroprevalence studies. Methods. During March-April 2006, cerebrospinal fluid samples from patients suspected to have meningitis in 3 epidemic villages were analyzed by culture or polymerase chain reaction. We assessed meningococcal carriage and serogroup-specific serum bactericidal antibody titers with baby rabbit complement (rSBA) in a representative population sample (N = 624; age range, 1-39 years). A serogroup A/C polysaccharide vaccine campaign occurred in parallel. Results. Cumulative incidence of Nm meningitis was 0.45% and varied among villages (0.08%-0.91%). NmA carriage prevalence was 16% without variation by vaccination status. NmA carriage and anti-NmA seroprevalence varied by village and incidence. In the 2 villages with highest incidence and seroprevalence, presence of rSBA titers ≤8 was associated with NmA carriage (odds ratio [OR], 9.33 [95% confidence interval {CI}, 1.90-45.91]) and vaccination ≥4 days earlier (OR, 0.10 [95% CI, .03-.32]). Visibly purulent or Nm meningitis was significantly associated with recent flulike symptoms and exposure to kitchen smoke (risk ratios >15). Conclusions. A surge of NmA carriage may be involved in the development of meningococcal epidemics and rapidly increase anti-NmA seroprevalence. Flulike infection and kitchen smoke may contribute to the strength of epidemics. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Study of a Localized Meningococcal Meningitis Epidemic in Burkina Faso: Incidence, Carriage, and Immunity.
|
---|---|
Autor/in / Beteiligte Person: | Mueller, Judith E. ; Yaro, Seydou ; Njanpop-Lafourcade, Berthe-Marie ; Drabo, Aly ; Idohou, Régina S. ; Kroman, Sita S. ; Sanou, Oumarou ; Diagbouga, Serge ; Traoré, Yves ; Sangaré, Lassana ; Borrow, Raymond ; Gessner, Bradford D. |
Link: | |
Zeitschrift: | Journal of Infectious Diseases, Jg. 204 (2011-12-01), Heft 11, S. 1787-1795 |
Veröffentlichung: | 2011 |
Medientyp: | academicJournal |
ISSN: | 0022-1899 (print) |
DOI: | 10.1093/infdis/jir623 |
Schlagwort: |
|
Sonstiges: |
|