B Cell Depletion in HIV-1 Subtype A Infected Ugandan Adults: Relationship to CD4 T Cell Count, Viral Load and Humoral Immune Responses.
In: PLoS ONE, Jg. 6 (2011-08-01), Heft 8, S. 1-11
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Zugriff:
To better understand the nature of B cell dysfunctions in subjects infected with HIV-1 subtype A, a rural cohort of 50 treatment-nai&vuml;e Ugandan patients chronically infected with HIV-1 subtype A was studied, and the relationship between B cell depletion and HIV disease was assessed. B cell absolute counts were found to be significantly lower in HIV-1+ patients, when compared to community matched negative controls (p,0.0001). HIV-1-infected patients displayed variable functional and binding antibody titers that showed no correlation with viral load or CD4+ T cell count. However, B cell absolute counts were found to correlate inversely with neutralizing antibody (NAb) titers against subtype A (p = 0.05) and subtype CRF02_AG (p = 0.02) viruses. A positive correlation was observed between subtype A gp120 binding antibody titers and NAb breadth (p = 0.02) and mean titer against the 10 viruses (p = 0.0002). In addition, HIV-1 subtype A sera showed preferential neutralization of the 5 subtype A or CRF02_AG pseudoviruses, as compared with 5 pseudoviruses from subtypes B, C or D (p,0.001). These data demonstrate that in patients with chronic HIV-1 subtype A infection, significant B cell depletion can be observed, the degree of which does not appear to be associated with a decrease in functional antibodies. These findings also highlight the potential importance of subtype in the specificity of cross-clade neutralization in HIV-1 infection. [ABSTRACT FROM AUTHOR]
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Titel: |
B Cell Depletion in HIV-1 Subtype A Infected Ugandan Adults: Relationship to CD4 T Cell Count, Viral Load and Humoral Immune Responses.
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Autor/in / Beteiligte Person: | Oballah, Peter ; Flach, Britta ; Eller, Leigh A. ; Eller, Michael A. ; Ouma, Benson ; Souza, Mark de ; Kibuuka, Hannah N. ; Wabwire-Mangen, Fred ; Brown, Bruce K. ; Michael, Nelson L. ; Robb, Merlin L. ; Montefiori, David ; Polonis, Victoria R. |
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Zeitschrift: | PLoS ONE, Jg. 6 (2011-08-01), Heft 8, S. 1-11 |
Veröffentlichung: | 2011 |
Medientyp: | academicJournal |
ISSN: | 1932-6203 (print) |
DOI: | 10.1371/journal.pone.0022653 |
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