Factors predictive of early death in patients receiving high-dose CHOP (ACVB regimen) for aggressive non-Hodgkin's lymphoma: a GELA study.
In: British Journal of Haematology, Jg. 118 (2002-07-01), Heft 1, S. 210-217
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Summary. Death during the induction phase of chemotherapy remains a common event in patients with aggressive non-Hodgkin's lymphoma (NHL). In a series of patients with aggressive NHL homogeneously treated with intensive induction chemotherapy [ACVB (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) regimen], we determined the clinical and biological parameters that were predictive of early death. Early death was defined as death, for whatever reason, occurring within 100 d of randomization. Predictive factors were identified by logistic regression and an index predictive for individual risk of early death was designed. Among the 2210 patients treated with ACVB, there were 162 (7·3%) early deaths. There was no significant reduction in the rate of early death between 1987 and 1998. In a multivariate analysis, age > 60 years, Eastern Cooperative Oncology Group performance status > 1, serum lactate dehydrogenase > normal, serum albumin < 30 g/l, leucocyte counts > 10 × 10 9 /l and haemoglobin levels < 8·5 g/dl were found to be independent predictive factors for early death. An early death index was designed, enabling the evaluation of the individual risk of early death in young (range 2–31% risk of early death) and elderly patients (range 5–53%). Clinical and biological parameters available at diagnosis can help physicians identify patients with aggressive lymphoma at low or high risk of early death. [ABSTRACT FROM AUTHOR]
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Factors predictive of early death in patients receiving high-dose CHOP (ACVB regimen) for aggressive non-Hodgkin's lymphoma: a GELA study.
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Autor/in / Beteiligte Person: | Dumontet, Charles ; Mounier, Nicolas ; Munck, Jean Nicolas ; Bosly, André ; Morschauser, Frank ; Simon, Daniele ; Marit, Gérald ; Casasnovas, Olivier ; Reman, Oumédaly ; Molina, Thierry ; Reyes, Felix ; Coiffier, Bertrand |
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Zeitschrift: | British Journal of Haematology, Jg. 118 (2002-07-01), Heft 1, S. 210-217 |
Veröffentlichung: | 2002 |
Medientyp: | academicJournal |
ISSN: | 0007-1048 (print) |
DOI: | 10.1046/j.1365-2141.2002.03565.x |
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