NXY-059 Does Not Significantly Interact With Furosemide in Healthy Volunteers.
In: Journal of Clinical Pharmacology, Jg. 46 (2006-12-01), Heft 12, S. 1417-1425
Online
academicJournal
Zugriff:
NXY-059 is a free radical-trapping neuroprotectant that reduces infarct size and preserves brain function in animal models of acute ischemic stroke. Acute ischemic stroke patients receiving NXY-059 may also be exposed to diuretics for treatment of heart failure or hypertension. NXY-059 and furosemide are partly eliminated by active tubular secretion via an organic anion transporter. This double-blind, randomized, crossover, placebo-controlled study investigated whether an infusion of NXY-059 (15 mg/mL) during 12 hours affects the diuretic and saluretic effects of a 30-mg intravenous bolus dose of furosemide (10 mg/mL) administered after 6 hours’ infusion, in 13 male and 11 female healthy subjects. The net increase in urine volume and sodium excretion in the interval of 6 to 12 hours was 4.15 L and 178 mmol/L, respectively, during NXY-059 treatment (P = .93) and 4.34 L and 190 mmol/L, respectively, during placebo treatment (P = .54). NXY-059 reduced the renal clearance of furosemide by 19% (P = .019), and furosemide reduced the renal clearance of NXY-059 by 8% (P = .005). NXY-059 was well tolerated. [ABSTRACT FROM PUBLISHER]
Copyright of Journal of Clinical Pharmacology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
NXY-059 Does Not Significantly Interact With Furosemide in Healthy Volunteers.
|
---|---|
Autor/in / Beteiligte Person: | Strid, Stig ; Nilsson, Dag ; Borgå, Olof ; Wemer, Johan ; Grahnén, Anders |
Link: | |
Zeitschrift: | Journal of Clinical Pharmacology, Jg. 46 (2006-12-01), Heft 12, S. 1417-1425 |
Veröffentlichung: | 2006 |
Medientyp: | academicJournal |
ISSN: | 0091-2700 (print) |
DOI: | 10.1177/0091270006293372 |
Sonstiges: |
|