Specific expression profile and prognosticsignificance of peroxiredoxins in grade II-IVastrocytic brain tumors.
In: BMC Cancer, Jg. 10 (2010), S. 104-113
Online
academicJournal
Zugriff:
Background: Peroxiredoxins (Prxs) have recently been suggested to have a role in tumorigenesis. Methods: We studied the expression of Prx I-VI and their relationship to patient survival in 383 grade II-IV diffuse astrocytic brain tumors. Results: Prx I positivity was found in 68%, Prx II in 84%, Prx III in 90%, Prx IV in 5%, Prx V in 4% and Prx VI in 47% of the tumors. Prx I and Prx II expression decreased significantly with increasing malignancy grade (p < 0.001 and p < 0.001). Patients with Prx I or Prx II positive tumors were significantly younger than the average age of all the patients (p = 0.014 and p = 0.005). A lower proliferation rate was associated with Prx I and Prx VI positive tumors (p = 0.019 and p = 0.033), and a lower apoptotic rate was found within Prx I and Prx II positive tumors (p < 0.001 and p = 0.007). Patients with Prx I and Prx II positive tumors had a significantly better survival rate than their Prxnegative counterparts (p = 0.0052 and p = 0.0002). Conclusion: The expression of Prx I and Prx II correlates with astrocytic tumor features, such as grade and patient age and proliferation activity (Prx I), and accordingly with patient survival. [ABSTRACT FROM AUTHOR]
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Titel: |
Specific expression profile and prognosticsignificance of peroxiredoxins in grade II-IVastrocytic brain tumors.
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Autor/in / Beteiligte Person: | Järvelä, Sally ; Rantala, Immo ; Rodriguez, Alejandra ; Kallio, Heini ; Parkkila, Seppo ; Kinnula, Vuokko L. ; Soini, Ylermi ; Haapasalo, Hannu |
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Zeitschrift: | BMC Cancer, Jg. 10 (2010), S. 104-113 |
Veröffentlichung: | 2010 |
Medientyp: | academicJournal |
ISSN: | 1471-2407 (print) |
DOI: | 10.1186/1471-2407-10-104 |
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