Urinary soluble egg antigen levels in Schistosoma haematobium infection in relation to sex and age of Kenyan schoolchildren following praziquantel treatment
In: Transactions of the Royal Society of Tropical Medicine & Hygiene, Jg. 103 (2009-10-01), Heft 10, S. 1024-1030
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Summary: Schistosoma haematobium soluble egg antigen (SEA) secreted in urine can be assayed to determine egg tissue load and hence morbidity in infected individuals. A cohort of 158 infected children aged 4–18 years was followed-up for 33 days pre and post treatment with a single dose of praziquantel. There was a significant difference in the prevalence of S. haematobium between males and females (P < 0.05). There were also significant differences in egg counts between age group ≤5 years compared with 6–8 years, 9–11 years and 12–14 years, and age group ≥15 years compared with 6–8 years, 9–11 years and 12–14 years (P < 0.05). Comparison of SEA among age groups indicated a significant difference between age group ≤5 years compared with 9–11 years, 12–14 years and ≥15 years, and age group ≥15 years compared with 9–11 years and 12–14 years (P < 0.05). There was a statistically significant correlation between levels of SEA and egg output (r 2 =0.961, P =0.010). These results are useful in the development of a SEA-based dipstick assay for field diagnosis of urinary schistosomiasis. [Copyright &y& Elsevier]
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Urinary soluble egg antigen levels in Schistosoma haematobium infection in relation to sex and age of Kenyan schoolchildren following praziquantel treatment
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Autor/in / Beteiligte Person: | Kihara, Jimmy H. ; Njagi, Eliud N.M. ; Kenya, Eucharia U. ; Mwanje, Marium T. ; Odek, Adel E. ; van Dam, Govert ; Kahama, Anthony I. ; Ouma, John H. |
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Zeitschrift: | Transactions of the Royal Society of Tropical Medicine & Hygiene, Jg. 103 (2009-10-01), Heft 10, S. 1024-1030 |
Veröffentlichung: | 2009 |
Medientyp: | academicJournal |
ISSN: | 0035-9203 (print) |
DOI: | 10.1016/j.trstmh.2009.04.021 |
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