Role of RHAMM within the hierarchy of well-established prognostic factors in colorectal cancer.
In: Gut, Jg. 57 (2008-10-01), Heft 10, S. 1413-1419
Online
academicJournal
Zugriff:
Objective: To compare the independent prognostic effect of a panel of immunohistochemical protein markers in colorectal cancer (CRC) and determine their ranking among the established prognostic factors T stage, N stage, vascular invasion, tumour budding and tumour grade. Design: A tissue microarray of 1420 CRCs was immunostained for 23 markers and mismatch repair (MMR) proteins. Immunoreactivity was assessed semi-quantitatively. Receiver operating characteristic (ROC) curves were used to determine cut-off scores for tumour marker positivity. Survival time was investigated for each marker in multivariable analysis with T stage, N stage, vascular invasion, tumour budding and tumour grade. The hazard ratio (HR) was used to compare the prognostic effect of each marker on 5 year survival. Results: To the standard prognostic features, only six markers added independent prognostic information including receptor for hyaluronic acid mediated motility (RHAMM) (HR = 2.39 (1.88 to 3.05)), epidermal growth factor receptor (HR = 1.65 (1.31 to 2.09)), tumour infiltrating lymphocytes (HR = 0.7 (0.54 to 0.92)), urokinase plasminogen activator (HR = 1.38)1.09 to 1.75)), Raf-1 kinase inhibitor protein (HR = 0.75 (0.58 to 0.96)) and mammalian sterile 20-like kinase 1 (MST1) (HR = 0.75 (0.58 to 0.95). Diffuse (>90% staining) expression of RHAMM ranked above T stage, vascular invasion, tumour budding and tumour grade in terms of adverse prognostic significance and was associated with distant metastasis (p = 0.012) and with worse outcome in patients with metastatic disease (p = 0.031). Conclusions: The strong adverse effect of RHAMM on outcome in addition to its position within the hierarchy of well-established prognostic factors suggest that RHAMM should be considered a more important prognosticator than tumour grade, tumour budding and vascular invasion in patients with CRC. [ABSTRACT FROM AUTHOR]
Copyright of Gut is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Role of RHAMM within the hierarchy of well-established prognostic factors in colorectal cancer.
|
---|---|
Autor/in / Beteiligte Person: | Zlobec, I. ; Terracciano, L. ; Tornillo, L. ; Günthert, U. ; Vuong, T. ; Jass, J. R. ; Lugli, A. |
Link: | |
Zeitschrift: | Gut, Jg. 57 (2008-10-01), Heft 10, S. 1413-1419 |
Veröffentlichung: | 2008 |
Medientyp: | academicJournal |
ISSN: | 0017-5749 (print) |
DOI: | 10.1136/gut.2007.141192 |
Schlagwort: |
|
Sonstiges: |
|