Cost-effectiveness analysis of a universal vaccination programme with the 7-valent pneumococcal conjugate vaccine (PCV-7) in Sweden.
In: Scandinavian Journal of Infectious Diseases, Jg. 40 (2008-09-01), Heft 9, S. 721-729
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Zugriff:
The 7-valent pneumococcal conjugate vaccine (PCV-7) has proved to be highly effective against invasive pneumococcal disease and has also provided some protection against all-cause pneumonia and acute otitis media. The objective of this study was to evaluate the projected health benefits, costs and cost-effectiveness of vaccination with the 7-valent conjugated pneumococcal vaccine compared with no vaccination, in all infants in Sweden, taking herd immunity into account. A Markov model was used and a hypothetical birth cohort was simulated for a lifelong perspective. The results show that vaccination of 1 cohort could potentially prevent 9 cases of pneumococcal meningitis, 22 cases of pneumococcal septicaemia, 509 cases of hospitalized pneumonia, 7812 cases of acute otitis media, and 2.7 fatalities, among children 0-4 y of age and 6 episodes of pneumococcal meningitis and 167 cases of pneumococcal septicaemia among adults. The incremental cost per QALY and LY gained was estimated to €29,200 and €51,400, respectively. When herd immunity was accounted for, the cost per QALY and LY gained was estimated to €5500 and €6600, respectively. Thus, the health benefits of a national vaccination programmeme can be achieved within a 'moderate' or 'low' cost per QALY gained. [ABSTRACT FROM AUTHOR]
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Titel: |
Cost-effectiveness analysis of a universal vaccination programme with the 7-valent pneumococcal conjugate vaccine (PCV-7) in Sweden.
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Autor/in / Beteiligte Person: | Bergman, Annika ; Hjelmgren, Jonas ; Örtqvist, Åke ; Wisløff, Torbjørn ; Sønbø Kristiansen, Ivar ; Diaz Högberg, Liselotte ; M-S Persson, Kristina ; Persson, Ulf |
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Zeitschrift: | Scandinavian Journal of Infectious Diseases, Jg. 40 (2008-09-01), Heft 9, S. 721-729 |
Veröffentlichung: | 2008 |
Medientyp: | academicJournal |
ISSN: | 0036-5548 (print) |
DOI: | 10.1080/00365540802014872 |
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