Factors Determining the Heterogeneity of Malaria Incidence in Children in Kampala, Uganda.
In: Journal of Infectious Diseases, Jg. 198 (2008-08-01), Heft 3, S. 393-400
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Background. Malaria risk may be heterogeneous in urban areas of Africa. Identifying those at highest risk for malaria may lead to more targeted approaches to malaria control. Methods. A representative sample of 558 children aged 1-10 years were recruited from a census population in a single parish of Kampala and followed up for 2 years. Malaria was diagnosed when a child presented with a new episode of fever and a thick blood smear positive for parasites. Multivariate analysis was used to identify independent predictors of malaria incidence. Results. A total of 695 episodes of uncomplicated malaria were diagnosed after 901 person years of follow-up. Sickle cell trait (relative risk [RR], 0.68 [95% confidence interval {CI}, 0.52- 0.90]), glucose-6-phosphate dehydrogenase deficiency in female children (RR, 0.48 [95% CI, 0.31- 0.75]), and use of an insecticide-treated bed net (RR, 0.52 [95% CI, 0.32- 0.83]) were associated with a lower risk of malaria. The distance of the subject's residence from a swamp bordering the parish showed a strong "dose-response" relationship; living in the swamp was the strongest predictor of malaria risk (RR, 3.94 [95% CI, 2.61-5.97]). Conclusion. Malaria incidence was highly heterogeneous in this urban cohort of children. Malaria control interventions in urban areas should target populations living in pockets of high malaria risk. [ABSTRACT FROM AUTHOR]
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Factors Determining the Heterogeneity of Malaria Incidence in Children in Kampala, Uganda.
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Autor/in / Beteiligte Person: | Clark, Tamara D. ; Greenhouse, Bryan ; Njama-Meya, Denise ; Nzarubara, Bridget ; Maiteki-Sebuguzi, Catherine ; Staedke, Sarah G. ; Seto, Edmund ; Kamya, Moses R. ; Rosenthal, Philip J. ; Dorsey, Grant |
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Zeitschrift: | Journal of Infectious Diseases, Jg. 198 (2008-08-01), Heft 3, S. 393-400 |
Veröffentlichung: | 2008 |
Medientyp: | academicJournal |
ISSN: | 0022-1899 (print) |
DOI: | 10.1086/589778 |
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