Prevention of anaemia in pregnancy using insecticide-treated bednets and sulfadoxine-pyrimethamine in a highly malarious area of Kenya: a randomized controlled trial
In: Transactions of the Royal Society of Tropical Medicine & Hygiene, Jg. 97 (2003-05-01), Heft 3, S. 277-282
Online
academicJournal
Zugriff:
To compare the effects of intermittent treatment with sulfadoxine-pyrimethamine (SP) given during the second and third trimester of pregnancy, the use of insecticide-treated nets (ITN), or the combination of both on haemoglobin (Hb) levels during pregnancy, a randomized, placebo-controlled intervention trial was conducted in a malaria-endemic area of western Kenya from July 1997 to September 1999. Primigravidae and secundigravidae were enrolled into the study and randomized into 4 intervention groups: (i) ITNs and SP, (ii) ITNs and placebo SP, (iii) SP alone, and (iv) placebo SP. All groups were offered case management and iron and folic acid supplementation. Seven hundred and fifty-two women were followed until delivery (53.2% were primigravidae and 46.8% secundigravidae). Among primigravidae in all the groups there was a significant improvement in Hb levels at delivery (107.6 g/L) compared with recruitment (101.9 g/L) ( P < 0.006 ) with the greatest improvement in the combination ITNs + SP group. The protective efficacy of ITNs + SP on anaemia was 55.8% (95% CI 30.6-71.8), of SP alone 50.9% (95% CI 22.2-69.0), and of ITNs 41.6% (95% CI 9.8-62.3). Among secundigravidae, Hb levels were slightly lower at delivery compared with recruitment ( P = 0.03 ). It was concluded that malaria is a major cause of anaemia in primigravidae but that other causes play a more significant role in secundigravidae, and that intermittent treatment with SP or use of ITNs benefits primigravidae more than secundigravidae. [Copyright &y& Elsevier]
Copyright of Transactions of the Royal Society of Tropical Medicine & Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Prevention of anaemia in pregnancy using insecticide-treated bednets and sulfadoxine-pyrimethamine in a highly malarious area of Kenya: a randomized controlled trial
|
---|---|
Autor/in / Beteiligte Person: | Njagi, Joseph Kiambo ; Magnussen, Pascal ; Estambale, Benson ; Ouma, John ; Mugo, Benbolt |
Link: | |
Zeitschrift: | Transactions of the Royal Society of Tropical Medicine & Hygiene, Jg. 97 (2003-05-01), Heft 3, S. 277-282 |
Veröffentlichung: | 2003 |
Medientyp: | academicJournal |
ISSN: | 0035-9203 (print) |
DOI: | 10.1016/S0035-9203(03)90141-6 |
Schlagwort: |
|
Sonstiges: |
|