Recurrent Aortic Thromboembolism Associated With TET2 Mutation in Chronic Myelomonocytic Leukemia.
In: Journal of Investigative Medicine High Impact Case Reports, 2024-01-12, S. 1-3
Online
academicJournal
Zugriff:
Ten-eleven translocation 2 (TET2) plays a pivotal role in epigenetic regulation, cell differentiation, and the inflammatory response. It also mediates the transcriptional regulation for inflammatory cytokines, particularly interleukin-6. While loss-of-function mutation in TET2 has been associated with hematological malignancies, it has been increasingly recognized to cause atherosclerotic disease. The increased atherogenicity is thought to be the result of increased production of pro-inflammatory interleukin-1β cytokines following activation of NLRP3 inflammasomes. We present a unique case of recurrent atherothrombosis in an elderly man who was diagnosed with chronic myelomonocytic leukemia in the setting of TET2 mutation. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Investigative Medicine High Impact Case Reports is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Recurrent Aortic Thromboembolism Associated With TET2 Mutation in Chronic Myelomonocytic Leukemia.
|
---|---|
Autor/in / Beteiligte Person: | Bukhari, Syed ; Saati, Ammar ; Abuhalimeh, Batool ; Ouma, Geoffrey |
Link: | |
Zeitschrift: | Journal of Investigative Medicine High Impact Case Reports, 2024-01-12, S. 1-3 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 2324-7096 (print) |
DOI: | 10.1177/23247096231224366 |
Sonstiges: |
|