Frequency of dihydropyrimidine dehydrogenase and UDP-glucuronosyltransferase 1A1 variants in cancer patients requiring chemotherapy: A single-center study in southern India.
In: Journal of Clinical & Basic Research, Jg. 7 (2023), Heft 1, S. 6-8
Online
academicJournal
Zugriff:
Background: Cancer treatment using drugs metabolized by the enzymes dihydropyrimidine dehydrogenase (DPYD) and UDP-glucuronosyltransferase 1A1 (UGT1A1) results in adverse effects for some patients. This is frequently reported in cancer patients undergoing therapy with 5-fluorouracil, capecitabine, and irinotecan who have polymorphisms in the genes coding for DPYD and UGT1A1. The present study assessed the DPYD*2A and UGT1A1*28 polymorphisms in cancer patients before starting chemotherapy to identify the individuals at risk of developing an adverse drug reaction. Methods: Genomic DNA was isolated from patients and subjected to PCR amplification using specific primers to study DPYD*2A and UGT1A1*28 polymorphisms. The PCR products were assessed by Sanger sequencing for establishing the genotype. Results: Of 75 cancer patients requiring treatment with drugs metabolized by DPYD and UGT1A1, 2 (2.66%) and 12 (29.27%) were likely to have adverse reactions based on DPYD*2A and UGT1A1*28 genotyping, respectively. Conclusion: Our findings indicate that carrying out genotyping for these two polymorphisms will help a large number of patients requiring treatment with 5-fluorouracil, irinotecan, and capecitabine. [ABSTRACT FROM AUTHOR]
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Frequency of dihydropyrimidine dehydrogenase and UDP-glucuronosyltransferase 1A1 variants in cancer patients requiring chemotherapy: A single-center study in southern India.
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Autor/in / Beteiligte Person: | Gangavarapu, Kevin ; Bora, Nandini Shyamali ; Srinivas, Maddali ; Hasan, Qurratulain |
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Zeitschrift: | Journal of Clinical & Basic Research, Jg. 7 (2023), Heft 1, S. 6-8 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 2538-3736 (print) |
DOI: | 10.29252/JCBR.7.1.6 |
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