Phycocyanin improved alcohol-induced hepatorenal toxicity and behavior impairment in Wistar rats.
In: Drug & Chemical Toxicology, Jg. 46 (2023-11-25), Heft 6, S. 1187-1192
academicJournal
Zugriff:
The aim of this study was to investigate a potential preventive effect of phycocyanin extract from Spirulina platensis against ethanol- induced hepatorenal toxicity and cognitive behavior impairment in male Wistar rats. The animals were randomly and equally divided into four groups (six animals each): control group received saline solution, ethanol (EtOH) group was injected intraperitoneally with 1 ml/kg of ethanol solution 38% (w/v), phycocyanin groups were treated with 25 (PC1) or 50 (PC2) mg/kg phycocyanin extract followed by ethanol administration. All treatments were conducted for 14 successive days. Results revealed that ethanol induced oxidative stress in brain, liver, and kidney by increasing lipid peroxidation level and SOD and CAT activities. Serum biochemical perturbations were also observed in EtOH group, which was indicated by a significant elevation in ALT, AST, cholesterol, triglycerides, creatinine, and urea levels. Combined exposure to EtOH with phytocyanin contracted these biochemical alterations. Phycocyanin decreased also EtOH-induced anxiety and ameliorated exploratory behavior assessed by the elevated-plus maze and open field tests respectively. [ABSTRACT FROM AUTHOR]
Copyright of Drug & Chemical Toxicology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Phycocyanin improved alcohol-induced hepatorenal toxicity and behavior impairment in Wistar rats.
|
---|---|
Autor/in / Beteiligte Person: | Oumayma, Boukari ; Wahid, Khemissi ; Soumaya, Ghodhbane ; Olfa, Tebourbi ; Ben Rhouma, Khemais ; Mohsen, Sakly ; Dorsaf, Hallegue |
Zeitschrift: | Drug & Chemical Toxicology, Jg. 46 (2023-11-25), Heft 6, S. 1187-1192 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 0148-0545 (print) |
DOI: | 10.1080/01480545.2022.2139843 |
Schlagwort: |
|
Sonstiges: |
|