Effect of clinical features on antiseizure medication doses in patients with newly diagnosed epilepsy.
In: Frontiers in Neurology, 2023-08-21, S. 1-11
Online
academicJournal
Zugriff:
Objective: We evaluate the effect of distinct clinical features on anti-seizure medication (ASM) doses in seizure-free and not seizure-free patients aged ≥16 years with new-onset epilepsy. Materials and methods: This study included 459 patients with a validated diagnosis of epilepsy. The most prescribed ASMs were oxcarbazepine (OXC; n = 307), followed by valproic acid (VPA; n = 115), carbamazepine (CBZ; n = 81), and lamotrigine (LTG; n = 67). The seizure freedom rate with their first or subsequent ASM was 88.0%. A retrospective analysis of patient records was performed to determine any association between doses of ASMs and patient characteristics. Results: The median OXC dose in seizure-free patients aged >60 years was 600mg compared to 900mg in younger patients.When controlling for age but not in an unadjusted model, the median dose of OXC was lower (300mg, p = 0.018) for seizure-free patients compared to non-seizure-free patients, and the median dose of OXC was also 300mg lower among older patients aged >60 years (p < 0.001). The median OXC doses for men aged ≤60 years were 300mg higher than for women aged >60 years (900mg vs. 600mg, p = 0.021). The median dose of VPA was 400mg higher inmen than in women (p<0.001) and 400mg higher in not seizure-free patients compared to seizure-free patients only when adjusting for sex (p < 0.001). Higher median doses for CBZ were registered with FAS compared with FBTCS (difference in median doses of 200mg; p = 0.017). Conclusion: Significant OXC dose differences were detected between age groups, whereas VPA dosing was different in men and women. Moreover, CBZ doses were dependent on some seizure types. These data allow for the individualization of the initial target dosing based on key clinical characteristics. [ABSTRACT FROM AUTHOR]
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Effect of clinical features on antiseizure medication doses in patients with newly diagnosed epilepsy.
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Autor/in / Beteiligte Person: | Hersi, Hire ; Peltola, Jukka ; Raitanen, Jani ; Saarinen, Jukka T. |
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Zeitschrift: | Frontiers in Neurology, 2023-08-21, S. 1-11 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1664-2295 (print) |
DOI: | 10.3389/fneur.2023.1159339 |
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