Genetic differentiation in East African ethnicities and its relationship with endurance running success.
In: PLoS ONE, Jg. 17 (2022-05-19), Heft 5, S. 1-20
Online
academicJournal
Zugriff:
Since the 1960s, East African athletes, mainly from Kenya and Ethiopia, have dominated long-distance running events in both the male and female categories. Further demographic studies have shown that two ethnic groups are overrepresented among elite endurance runners in each of these countries: the Kalenjin, from Kenya, and the Oromo, from Ethiopia, raising the possibility that this dominance results from genetic or/and cultural factors. However, looking at the life history of these athletes or at loci previously associated with endurance athletic performance, no compelling explanation has emerged. Here, we used a population approach to identify peaks of genetic differentiation for these two ethnicities and compared the list of genes close to these regions with a list, manually curated by us, of genes that have been associated with traits possibly relevant to endurance running in GWAS studies, and found a significant enrichment in both populations (Kalenjin, P = 0.048, and Oromo, P = 1.6x10 -5 ). Those traits are mainly related to anthropometry, circulatory and respiratory systems, energy metabolism, and calcium homeostasis. Our results reinforce the notion that endurance running is a systemic activity with a complex genetic architecture, and indicate new candidate genes for future studies. Finally, we argue that a deterministic relationship between genetics and sports must be avoided, as it is both scientifically incorrect and prone to reinforcing population (racial) stereotyping. [ABSTRACT FROM AUTHOR]
Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Genetic differentiation in East African ethnicities and its relationship with endurance running success.
|
---|---|
Autor/in / Beteiligte Person: | Zani, André L. S. ; Gouveia, Mateus H. ; Aquino, Marla M. ; Quevedo, Rodrigo ; Menezes, Rodrigo L. ; Rotimi, Charles ; Lwande, Gerald O. ; Ouma, Collins ; Mekonnen, Ephrem ; Fagundes, Nelson J. R. |
Link: | |
Zeitschrift: | PLoS ONE, Jg. 17 (2022-05-19), Heft 5, S. 1-20 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 1932-6203 (print) |
DOI: | 10.1371/journal.pone.0265625 |
Schlagwort: |
|
Sonstiges: |
|