Analysis of the influence of glutathione S-transferase (GSTM1 and GSTT1) genes on the risk of essential hypertension.
In: Annals of Human Biology, Jg. 48 (2021-12-01), Heft 7/8, S. 585-589
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Zugriff:
Essential hypertension (EH) results from a complex interaction between environmental factors and an individual's genetic background. To assess the relationship between polymorphisms in GSTM1 and GSTT1 and the risk of EH. A multiplex-PCR was used to identify the genotypic profiles of GSTM1 and GSTT1 in 160 patients and 210 controls. The frequency of GSTM1-null genotype was higher in patients younger than 61 years when compared to those over 61 years. Interestingly, GSTT1-null was significantly associated with the risk of EH (OR 4; 95% CI 2.6–6.3; p < 0.0001). While GSTM1-null showed no trend (OR 0.7; 95% CI 0.5–1.1, p = 0.12). Individuals carrying the combined GSTT1-null/GSTM1-null were 2.4 times more at risk for hypertension compared to those harbouring the combined GSTT1-present/GSTM1-present genotype (OR 2.4; 95% CI 1.3–4.4; p = 0.005). Additionally, the presence of the combined GSTT1-null/GSTM1-present was associated with an increased risk of EH compared to GSTT1-present/GSTM1-present carriers (OR 6.75; 95% CI 3.4–13.2; p < 0.0001). This study showed that the GSTT1-null alone or in interaction with GSTM1-present or GSTM1-null was associated with a higher risk of hypertension. Moreover, the GSTM1-null seems to be associated with the age of onset of hypertension. [ABSTRACT FROM AUTHOR]
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Titel: |
Analysis of the influence of glutathione S-transferase (GSTM1 and GSTT1) genes on the risk of essential hypertension.
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Autor/in / Beteiligte Person: | Nassereddine, Sanaa ; Habbal, Rachida ; Kassogue, Yaya ; Kaltoum, Ait Boujmia Oum ; Farah, Korchi ; Majda, Haraka ; Rhizlane, Abou Elfath ; Nadifi, Sellama ; Dehbi, Hind |
Zeitschrift: | Annals of Human Biology, Jg. 48 (2021-12-01), Heft 7/8, S. 585-589 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 0301-4460 (print) |
DOI: | 10.1080/03014460.2022.2039291 |
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