Respective prevalence of high‐risk HPVgenotypes in cervical neoplasia in Senegal.
In: Journal of Medical Virology, Jg. 93 (2021-08-01), Heft 8, S. 5110-5117
Online
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Zugriff:
Objectives: With the perspective of prophylactic vaccination against high‐risk human papillomavirus (HPV), we analyzed the viral epidemiology of cervical neoplasia in Senegal. Methods: All patients were treated at the Institut Joliot Curie du Cancer in Dakar. HPV genotypes were characterized using a real‐time polymerase chain reaction‐based approach and sequencing. Results: Histologically, there were 224 invasive carcinomas, 17 high‐grade intraepithelial neoplasia (CIN), and five undetermined histologies. Molecular analysis was conclusive in 241 cases. HPV DNA was found in 207/241 (85.9%) cases while 34/241 (14.1%) remained HPV negative. There was one single genotype in 127/207 (61.4%) cases and several in 80/207 (38.6%) corresponding to 308 genotypes identified. Viral genotyping found HPV16 in 175 (56.8%) cases, HPV18 in 45 (14.6%), HPV45 in 40 (13.0%), HPV58 in 35 (11.4%), HPV33 in 6 (2.0%), HPV35 in 3 (1.0%), HPV31 in 2 (0.6%), HPV39 and HPV56 in one (0.3% each). Conclusion: Our analysis showed that 98.4% of the HPV‐positive cases were associated with viral genotypes covered by the 9‐valent HPV vaccine. However, 14.1% of cases remained HPV negative. Therefore, prophylactic vaccination using a 9‐valent vaccine should dramatically reduce the incidence of HPV‐associated neoplasia but the detection and treatment of CIN remain necessary for the optimal prevention of cervical cancer. [ABSTRACT FROM AUTHOR]
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Titel: |
Respective prevalence of high‐risk HPVgenotypes in cervical neoplasia in Senegal.
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Autor/in / Beteiligte Person: | Diop‐Ndiaye, Halimatou ; Sastre‐Garau, Xavier ; Drame, Aboubacry ; Dembele, Birama ; Ba, Nafissatou N. ; Diop‐Diongue, Oumy ; Mbow, Madeleine ; Diakhaby, Mba E. B. ; Woto‐Gaye, Gisele ; Toure Kane, Coumba ; Diop, Mamadou |
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Zeitschrift: | Journal of Medical Virology, Jg. 93 (2021-08-01), Heft 8, S. 5110-5117 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 0146-6615 (print) |
DOI: | 10.1002/jmv.27020 |
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