Associations Between IFI44L Gene Variants and Rates of Respiratory Tract Infections During Early Childhood.
In: Journal of Infectious Diseases, Jg. 223 (2021), Heft 1, S. 157-165
Online
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Zugriff:
Background: Genetic heterogeneity in type I interferon (IFN)-related gene IFI44L may account for variable susceptibility to respiratory tract infections (RTIs) in children. Methods: In 2 prospective, population-based birth cohorts, the STEPS Study and the FinnBrain Birth Cohort Study, IFI44L genotypes for rs273259 and rs1333969 were determined in relation to the development of RTIs until 1 or 2 years of age, respectively. At age 3 months, whole-blood transcriptional profiles were analyzed and nasal samples were tested for respiratory viruses in a subset of children. Results: In the STEPS Study (n = 1135), IFI44L minor/minor gene variants were associated with lower rates of acute otitis media episodes (adjusted incidence rate ratio, 0.77 [95% confidence interval, .61-.96] for rs273259 and 0.74 [.55-.99] for rs1333969) and courses of antibiotics for RTIs (0.76 [.62-.95] and 0.73 [.56-.97], respectively. In the FinnBrain cohort (n = 971), IFI44L variants were associated with lower rates of RTIs and courses of antibiotics for RTIs. In respiratory virus-positive 3-month-old children, IFI44L gene variants were associated with decreased expression levels of IFI44L and several other IFN-related genes. Conclusions: Variant forms of IFI44L gene were protective against early-childhood RTIs or acute otitis media, and they attenuated IFN pathway activation by respiratory viruses. [ABSTRACT FROM AUTHOR]
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Associations Between IFI44L Gene Variants and Rates of Respiratory Tract Infections During Early Childhood.
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Autor/in / Beteiligte Person: | Lempainen, Johanna ; Korhonen, Laura S ; Kantojärvi, Katri ; Heinonen, Santtu ; Toivonen, Laura ; Räty, Panu ; Ramilo, Octavio ; Mejias, Asuncion ; Laine, Antti-Pekka ; Vuorinen, Tytti ; Waris, Matti ; Karlsson, Linnea ; Karlsson, Hasse ; Paunio, Tiina ; Peltola, Ville |
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Zeitschrift: | Journal of Infectious Diseases, Jg. 223 (2021), Heft 1, S. 157-165 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 0022-1899 (print) |
DOI: | 10.1093/infdis/jiaa341 |
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