Neisseria meningitidis Serogroup W Meningitis Epidemic in Togo, 2016.
In: Journal of Infectious Diseases, Jg. 220 (2019-12-02), S. S216- (9S.)
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Background During 2014, 4 regions in Togo within the African meningitis belt implemented vaccination campaigns with meningococcal serogroup A conjugate vaccine (MACV). From January to July 2016, Togo experienced its first major Neisseria meningitidis serogroup W (NmW) outbreak. We describe the epidemiology, response, and management of the outbreak. Methods Suspected, probable, and confirmed cases were identified using World Health Organization case definitions. Through case-based surveillance, epidemiologic and laboratory data were collected for each case. Cerebrospinal fluid specimens were analyzed by polymerase chain reaction, culture, or latex agglutination. Vaccination campaigns were conducted in affected districts. Results From January 11 to July 5, 2016, 1995 suspected meningitis cases were reported, with 128 deaths. Among them, 479 (24.0%) were confirmed by laboratory testing, and 94 (4.7%) and 1422 (71.3%) remained as probable and suspected cases, respectively. Seven epidemic districts had cumulative attack rates greater than 100 per 100 000 population. Of the confirmed cases, 91.5% were NmW; 39 of 40 available NmW isolates were sequence type-11/clonal complex-11. Conclusions This outbreak demonstrates that, although high coverage with MACV has reduced serogroup A outbreaks, large meningococcal meningitis outbreaks due to other serogroups may continue to occur; effective multivalent meningococcal conjugate vaccines could improve meningococcal disease prevention within meningitis belt populations. [ABSTRACT FROM AUTHOR]
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Neisseria meningitidis Serogroup W Meningitis Epidemic in Togo, 2016.
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Autor/in / Beteiligte Person: | Mounkoro, Didier ; Nikiema, Christelle S ; Maman, Issaka ; Sakandé, Souleymane ; Bozio, Catherine H ; Tall, Haoua ; Sadji, Adodo Yao ; Njanpop-Lafourcade, Berthe-Marie ; Sibabe, Agoro ; Landoh, Dadja E ; Abodji, Essofa O ; Kodjo, Agbenoko ; Tamekloe, Tsidi A ; Essoh, Téné Alima ; Maba, Détèma W ; Gessner, Bradford D ; Moïsi, Jennifer C |
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Zeitschrift: | Journal of Infectious Diseases, Jg. 220 (2019-12-02), S. S216- (9S.) |
Veröffentlichung: | 2019 |
Medientyp: | academicJournal |
ISSN: | 0022-1899 (print) |
DOI: | 10.1093/infdis/jiz330 |
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