A New Sequence Type of Neisseria meningitidis Serogroup C Associated With a 2016 Meningitis Outbreak in Mali.
In: Journal of Infectious Diseases, Jg. 220 (2019-12-02), S. S190- (8S.)
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Zugriff:
In 2016, Mali reported a bacterial meningitis outbreak consisting of 39 suspected cases between epidemiologic weeks 9 and 17 with 15% case fatality ratio in the health district of Ouéléssebougou, 80 kilometers from the capital Bamako. Cerebrospinal fluid specimens from 29 cases were tested by culture and real-time polymerase chain reaction; 22 (76%) were positive for bacterial meningitis pathogens, 16 (73%) of which were Neisseria meningitidis (Nm). Of the Nm-positive specimens, 14 (88%) were N meningitidis serogroup C (NmC), 1 was NmW, and 1 was nongroupable. Eight NmC isolates recovered by culture from the outbreak were characterized using whole genome sequencing. Genomics analysis revealed that all 8 isolates belonged to a new sequence type (ST) 12446 of clonal complex 10217 that formed a distinct clade genetically similar to ST-10217, a NmC strain that recently caused large epidemics of meningitis in Niger and Nigeria. The emergence of a new ST of NmC associated with an outbreak in the African meningitis belt further highlights the need for continued molecular surveillance in the region. [ABSTRACT FROM AUTHOR]
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A New Sequence Type of Neisseria meningitidis Serogroup C Associated With a 2016 Meningitis Outbreak in Mali.
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Autor/in / Beteiligte Person: | Sanogo, Yibayiri Osee ; Guindo, Ibréhima ; Diarra, Seydou ; Retchless, Adam C ; Abdou, Mahamadou ; Coulibaly, Souleymane ; Maiga, Mahamadou Farka ; Coumaré, Mama ; Diarra, Bakary ; Chen, Alexander ; Chang, How-Yi ; Vuong, Jeni T ; Acosta, Anna M ; Sow, Samba ; Novak, Ryan T ; Wang, Xin |
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Zeitschrift: | Journal of Infectious Diseases, Jg. 220 (2019-12-02), S. S190- (8S.) |
Veröffentlichung: | 2019 |
Medientyp: | academicJournal |
ISSN: | 0022-1899 (print) |
DOI: | 10.1093/infdis/jiz272 |
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