De optimale dosering voor een continu infuus flucloxacilline bij niet-kritisch zieke patiënten. (Dutch/Flemish)
In: Nederlands Platform voor Farmaceutisch Onderzoek, Jg. 4 (2019-04-30), S. 1-6
academicJournal
Zugriff:
BACKGROUND Flucloxacillin is approved for intermittent dosing. The anti-bacterial activity of flucloxacillin is time dependent so con-tinuous infusion is probably more effective. Furthermore, for some patients continuous dosing can have practical benefits. Currently, the optimal flucloxacillin dosage for continuous infusion is unknown.OBJECTIVETo determine the optimal dosage for continuous flucloxa-cillin infusion in non-critically ill patients.METHODSUnbound flucloxacillin levels of 30 patients receiving intra venous flucloxacillin were analysed using non-linear mixed effects modelling. A Monte-Carlo simulation was used to assess the dosage needed to treat bacteria with a MIC of 0.25-2 mg/L in > 90% of the population.RESULTSA dosage of 4 g/24 hours was sufficient for 93.4% of the population to obtain a target of 100% fT > MIC of 0.5 mg/L. In 88.9% of the population a dosage of 12 g/24 hours was sufficient for a MIC of 2 mg/L, being the clinical breakpoint for S. aureus.CONCLUSIONThis simulation study showed that 4 g/24 hours is sufficient to reach unbound flucloxacillin levels exceeding 0.5 mg/L, the most common MICs found for S. aureus, in non-critically ill patients. In case of toxicity or if patients are not responding to a regular dosage, we advise to alter the dosage based on unbound flucloxacillin levels and the MIC. [ABSTRACT FROM AUTHOR]
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Titel: |
De optimale dosering voor een continu infuus flucloxacilline bij niet-kritisch zieke patiënten. (Dutch/Flemish)
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Autor/in / Beteiligte Person: | Wilkes, S. ; van Berlo, I. ; ten Oever, J. ; Jansman, F. ; ter Heine, R. |
Zeitschrift: | Nederlands Platform voor Farmaceutisch Onderzoek, Jg. 4 (2019-04-30), S. 1-6 |
Veröffentlichung: | 2019 |
Medientyp: | academicJournal |
ISSN: | 2468-5445 (print) |
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