Serum Soluble Transferrin Receptor Concentrations Are Elevated in Congolese Children with Glucose-6-Phosphate Dehydrogenase Variants, but Not Sickle Cell Variants or α-Thalassemia.
In: Journal of Nutrition, Jg. 147 (2017-09-01), Heft 9, S. 1785-1794
Online
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Zugriff:
Background: Anemia is common in Congolese children, and inherited blood disorders may be a contributing cause. The presence of sickle cell variants, X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency and α-thalassemia, has been previously reported. G6PD A- deficiency is characterized by the co-inheritance of G6PD 376 and 202 variants and is common in sub-Saharan Africa.Objective: We aimed to measure the associations between inherited blood disorders and hemoglobin, ferritin, and soluble transferrin receptor (sTfR) concentrations in Congolese children.Methods: Venous blood was collected from 744 children aged 6-59 mo from 2 provinces. We measured biomarkers of nutritional and inflammation status and malaria. Pyrosequencing was used to detect sickle cell variants. Polymerase chain reaction was used to detect G6PD variants and α-thalassemia deletions.Results: Overall, 11% of children had a sickle cell variant, 19% of boys were G6PD A- hemizygotes, 12% and 10% of girls were G6PD A- hetero- or homozygotes, respectively, and 12% of children had α-thalassemia. Multivariable linear regression models (adjusted for age, province, altitude, malaria, and biomarkers of nutritional and inflammation status) showed that G6PD A- hemizygous boys and G6PD 376 homozygous girls had higher sTfR concentrations [geometric mean ratios (95% CIs): 1.20 (1.03, 1.39) and 1.25 (1.02, 1.53), respectively] than children with no G6PD variants. Hemoglobin and ferritin concentrations were not independently associated with any of the inherited blood disorder genotypes.Conclusions: We found that 2 G6PD variant genotypes were associated with elevated sTfR concentrations, which limits the accuracy of sTfR as a biomarker of iron status in this population. [ABSTRACT FROM AUTHOR]
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Serum Soluble Transferrin Receptor Concentrations Are Elevated in Congolese Children with Glucose-6-Phosphate Dehydrogenase Variants, but Not Sickle Cell Variants or α-Thalassemia.
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Autor/in / Beteiligte Person: | Barker, Mikaela K. ; Henderson, Amanda M. ; Naguib, Karimah ; Vercauteren, Suzanne M. ; Devlin, Angela M. ; Albert, Arianne Y. ; Bahizire, Esto ; Tugirimana, Pierrot L. ; Akilimali, Pierre Z. ; Boy, Erick ; Green, Tim J. ; Karakochuk, Crystal D. |
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Zeitschrift: | Journal of Nutrition, Jg. 147 (2017-09-01), Heft 9, S. 1785-1794 |
Veröffentlichung: | 2017 |
Medientyp: | academicJournal |
ISSN: | 0022-3166 (print) |
DOI: | 10.3945/jn.117.252635 |
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