The relationship of serum vitamins A, D, E and LL-37 levels with allergic status, tonsillar virus detection and immune response.
In: PLoS ONE, Jg. 12 (2017-02-24), Heft 2, S. 1-13
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Zugriff:
Background: Tonsils have an active role in immune defence and inducing and maintaining tolerance to allergens. Vitamins A, D, and E, and antimicrobial peptide LL-37 may have immunomodulatory effects. We studied how their serum levels were associated with allergy status, intratonsillar/nasopharyngeal virus detection and intratonsillar expression of T cell- and innate immune response-specific cytokines, transcription factors and type I/II/III interferons in patients undergoing tonsillectomy. Methods: 110 elective tonsillectomy patients participated. Serum levels of vitamins A, 25(OH)D, and E, LL-37 and allergen-specific IgE as well as nasopharyngeal/intratonsillar respiratory viruses were analyzed. The mRNA expression of IFN-α, IFN-β, IFN-γ, IL-10, IL-13, IL-17, IL-28, IL-29, IL-37, TGF-β, FOXP3, GATA3, RORC2 and Tbet in tonsils were analyzed by quantitative RT-PCR. Results: The median age of the patients was 16 years (range 3–60), 28% of subjects had atopy, and 57% carried ≥1 respiratory virus in nasopharynx. Detection of viruses decreased by age. Higher vitamin A levels showed borderline significance with less viral detection (P = 0.056). Higher 25(OH)D was associated with less allergic rhinitis and atopy (P < 0.05) and higher vitamin E with less self-reported allergy (P < 0.05). In gene expression analyses, 25(OH)D was associated with higher IL-37, vitamin A with higher IFN-γ and vitamin E with less IL-28 (P < 0.05). LL-37 was associated with less FOXP3, RORC2 and IL-17 in tonsils (P < 0.05). Conclusions: Vitamin D and E levels were associated with less allergic disorders. Vitamin A was linked to antiviral and vitamin D with anti-inflammatory activity. LL-37 and was linked to T regulatory cell effects. [ABSTRACT FROM AUTHOR]
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The relationship of serum vitamins A, D, E and LL-37 levels with allergic status, tonsillar virus detection and immune response.
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Autor/in / Beteiligte Person: | Elenius, Varpu ; Palomares, Oscar ; Waris, Matti ; Turunen, Riitta ; Puhakka, Tuomo ; Rückert, Beate ; Vuorinen, Tytti ; Allander, Tobias ; Vahlberg, Tero ; Akdis, Mübeccel ; JrCamargo, Carlos A. ; Akdis, Cezmi A. ; Jartti, Tuomas |
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Zeitschrift: | PLoS ONE, Jg. 12 (2017-02-24), Heft 2, S. 1-13 |
Veröffentlichung: | 2017 |
Medientyp: | academicJournal |
ISSN: | 1932-6203 (print) |
DOI: | 10.1371/journal.pone.0172350 |
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