Absence of the DNA repair enzyme human 8-oxoguanine glycosylase is associated with an aggressive breast cancer phenotype.
In: British Journal of Cancer, Jg. 106 (2012-01-17), Heft 2, S. 344-347
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Zugriff:
Background: 8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is the most abundant marker of DNA damage and it reflects oxidative stress. Human 8-oxoguanine glycosylase (hOGG1) is a DNA-repair enzyme that participates in 8-oxodG removal. Methods: hOGG1 protein expression was immunohistochemically studied in 96 patients with local or locally advanced breast cancer and in 20 lesions of non-malignant breast disease. 8-OxodG levels had been previously determined in all patients. Results: hOGG1 was overexpressed in invasive vs non-invasive lesions (P=0.006). 8-OxodG and hOGG1 had a significant inverse association (P=0.046). Lack of hOGG1 expression was associated with the most poor prognostic factors of breast cancer. In addition, all triple-negative breast carcinomas (TNBCs) were hOGG1 negative (P=0.027 vs non-TNBCs). Patients with a lack of both hOGG1- and 8-oxodG immunostaining showed extremely poor breast cancer-specific survival compared with those with either 8-oxodG- or hOGG1-positive tumours (P<0.000005). Conclusion: The current results imply that absence of hOGG1 expression is associated with features of aggressive breast cancer. Tumours lacking both 8-oxodG and hOGG1 seem to indicate especially poor prognosis. [ABSTRACT FROM AUTHOR]
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Titel: |
Absence of the DNA repair enzyme human 8-oxoguanine glycosylase is associated with an aggressive breast cancer phenotype.
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Autor/in / Beteiligte Person: | Karihtala, P ; Kauppila, S ; Puistola, U ; Jukkola-Vuorinen, A |
Link: | |
Zeitschrift: | British Journal of Cancer, Jg. 106 (2012-01-17), Heft 2, S. 344-347 |
Veröffentlichung: | 2012 |
Medientyp: | academicJournal |
ISSN: | 0007-0920 (print) |
DOI: | 10.1038/bjc.2011.518 |
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