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Changes in CSF enzyme activity were studied after brain trauma for their prognostic value. Raised values of CPK and HBDH were demonstrated in the CSF of patients with severe brain injuries. Standardised cold lesions of the brain were induced in cats. The activities of the enzymes CPK, HBDH, LDH, GOT, GPT, and pseudocholinesterase were studied at half hour intervals in the cerebrospinal fluid and at hourly intervals in the serum. A statistically highly significant increase of all enzymes studied developed in the CSF. The greatest changes occurred within four hours of freezing. Large increases could occur in half an hour. Isoenzyme studies demonstrated that CPK and LDH were of cerebral origin. No consistently significant changes could be shown in the serum enzyme activity. It is concluded that after brain injuries, enzymes are released into the extracellular fluid of the brain and transported to the CSF. The limited value of a single enzyme estimation is emphasised. The results described seem to provide indirect evidence for transependymal flow of extracellular fluid in brain oedema.

Titel:	Cerebrospinal fluid enzymes in acute brain injury. 1. Dynamics of changes in CSF enzyme activity after acute experimental brain injury.
Autor/in / Beteiligte Person:	Maas, AI
Zeitschrift:	Journal of neurology, neurosurgery, and psychiatry, Jg. 40 (1977-07-01), Heft 7, S. 655
Veröffentlichung:	London : BMJ Publishing Group ; <i>Original Publication</i>: London : British Medical Association, 1977
Medientyp:	academicJournal
ISSN:	0022-3050 (print)
DOI:	10.1136/jnnp.40.7.655
Schlagwort:	Alanine Transaminase cerebrospinal fluid Animals Aspartate Aminotransferases cerebrospinal fluid Cats Cold Temperature adverse effects Creatine Kinase cerebrospinal fluid Hydroxybutyrate Dehydrogenase cerebrospinal fluid Isoenzymes cerebrospinal fluid L-Lactate Dehydrogenase cerebrospinal fluid Time Factors Brain Injuries cerebrospinal fluid Enzymes cerebrospinal fluid
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Neurol Neurosurg Psychiatry] 1977 Jul; Vol. 40 (7), pp. 655-65. MeSH Terms: Brain Injuries / cerebrospinal fluid ; Enzymes / cerebrospinal fluid ; Alanine Transaminase / cerebrospinal fluid ; Animals ; Aspartate Aminotransferases / cerebrospinal fluid ; Cats ; Cold Temperature / adverse effects ; Creatine Kinase / cerebrospinal fluid ; Hydroxybutyrate Dehydrogenase / cerebrospinal fluid ; Isoenzymes / cerebrospinal fluid ; L-Lactate Dehydrogenase / cerebrospinal fluid ; Time Factors References: Science. 1969 Dec 19;166(3912):1514-6. (PMID: 17655045) ; Am J Surg. 1960 May;99:713-6. (PMID: 13832155) ; Biochem Z. 1964 Jan 28;339:305-14. (PMID: 14126710) ; Proc Staff Meet Mayo Clin. 1956 Jun 27;31(13):391-9. (PMID: 13336129) ; Dtsch Med Wochenschr. 1965 Aug 13;90:1429-32. (PMID: 14319264) ; J Neurosurg. 1963 Dec;20:1050-63. (PMID: 14186107) ; JAMA. 1964 Jul 6;189:61-3. (PMID: 14149030) ; J Neuropathol Exp Neurol. 1962 Oct;21:579-96. (PMID: 14021594) ; J Neuropathol Exp Neurol. 1958 Oct;17(4):548-64. (PMID: 13588384) ; Exp Neurol. 1974 Oct;45(1):50-60. (PMID: 4137563) ; Nord Med. 1967 Mar 16;77(11):337-40. (PMID: 4960225) ; Psychiatr Neurol Neurochir. 1967 Sep-Oct;70(5):403-11. (PMID: 4168156) ; Acta Neurol Belg. 1973 Jul-Aug;73(4):229-40. (PMID: 4770126) ; Neurology. 1969 Oct;19(10):993-9. (PMID: 5387601) ; Clin Neurosurg. 1972;19:200-7. (PMID: 4637549) ; Rev Clin Esp. 1973 Jun 15;129(5):487-8. (PMID: 4732993) ; Clin Chim Acta. 1966 Mar;13(3):312-6. (PMID: 5943823) ; Acta Neurol Scand. 1968;44(1):124-9. (PMID: 5706981) ; J Neurosurg. 1974 Aug;41(2):224-8. (PMID: 4841877) ; Acta Neuropathol. 1969;13(1):12-28. (PMID: 4181971) ; Acta Neurochir (Wien). 1975;32(3-4):209-17. (PMID: 1225012) ; Am J Physiol. 1972 Mar;222(3):532-9. (PMID: 4623367) ; Cah Med. 1973 Dec 15;14(14):1141-7. (PMID: 4603519) ; J Neurosurg. 1972 May;36(5):625-33. (PMID: 5026547) ; Science. 1971 Jul 23;173(3994):330-2. (PMID: 4997797) ; Klin Wochenschr. 1967 Oct 1;45(19):973-7. (PMID: 5599666) ; Am J Physiol. 1967 Oct;213(4):1031-8. (PMID: 6051171) ; Arch Neurol. 1967 Feb;16(2):175-80. (PMID: 6018047) ; Acta Physiol Pharmacol Neerl. 1965;13(3):317-29. (PMID: 5883949) Substance Nomenclature: 0 (Enzymes) ; 0 (Isoenzymes) ; EC 1.1.1.27 (L-Lactate Dehydrogenase) ; EC 1.1.1.30 (Hydroxybutyrate Dehydrogenase) ; EC 2.6.1.1 (Aspartate Aminotransferases) ; EC 2.6.1.2 (Alanine Transaminase) ; EC 2.7.3.2 (Creatine Kinase) Entry Date(s): Date Created: 19770701 Date Completed: 19771229 Latest Revision: 20190501 Update Code: 20240513 PubMed Central ID: PMC492794

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Cerebrospinal fluid enzymes in acute brain injury. 1. Dynamics of changes in CSF enzyme activity after acute experimental brain injury.