Schistosomiasis mansoni in Kenya: relationship between infection and anaemia in schoolchildren at the community level.
In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Jg. 90 (1996), Heft 1, S. 48-54
Online
academicJournal
Zugriff:
Haematological surveys were carried out in 3 schools in 2 areas where Schistosoma mansoni is endemic in Machakos District, Kenya, before and after a treatment campaign using praziquantel. Earlier clinical impressions of differences in the levels of anaemia between the 2 areas were not confirmed. Although individual haemoglobin levels and haematocrits often fell below international norms, significant anaemia with abnormal red blood cell morphology was rare (< 5%), but varied between schools. Altitude could have accounted for some of these differences, but other factors, including diet and parasitism, were involved. Anaemia was associated with splenomegaly and, to a lesser extent, hepatosplenomegaly. Epidemic malaria (mainly Plasmodium falciparum) appeared to be the main cause of parasite-induced anaemia. There was no significant association with the scarce hookworm infections (mainly Necator americanus); nor did the much commoner S. mansoni cause severe anaemia at the community level, but haemoglobin levels dropped as its intensity increased. Treatment with praziquantel eliminated this trend except in a few subjects with splenomegaly alone (probably due to malaria) or with schistosomal hepatosplenic disease. Possible pathogenic mechanisms are reviewed, including the consumption of red blood cells by adult schistosomes as a possible cause of anaemia.
Titel: |
Schistosomiasis mansoni in Kenya: relationship between infection and anaemia in schoolchildren at the community level.
|
---|---|
Autor/in / Beteiligte Person: | Sturrock, RF ; Kariuki, HC ; Thiongo, FW ; Gachare, JW ; Omondi, BG ; Ouma, JH ; Mbugua, G ; Butterworth, AE |
Link: | |
Zeitschrift: | Transactions of the Royal Society of Tropical Medicine and Hygiene, Jg. 90 (1996), Heft 1, S. 48-54 |
Veröffentlichung: | 2013- : Oxford : Oxford University Press ; <i>Original Publication</i>: 1920- : London : Royal Society of Tropical Medicine and Hygiene, 1996 |
Medientyp: | academicJournal |
ISSN: | 0035-9203 (print) |
DOI: | 10.1016/s0035-9203(96)90477-0 |
Schlagwort: |
|
Sonstiges: |
|