Einzeltreffer — DigiBib

Background: Readmission rates following ileostomy formation are high. Dehydration and consecutive renal failure are common causes of readmission, potentially pronounced by drugs affecting the homeostasis. The aim of the study was to assess the risk of dehydration after ileostomy formation in patients treated with angiotensin-converting enzyme inhibitors (ACEI), angiotensin II receptor blockers (ARB) or diuretics.

Method: This nationwide population-based cohort study used data derived from the Colorectal Cancer Data Base of several Swedish healthcare registers. The study included all patients operated on with elective anterior resection and temporary ileostomy for rectal cancer clinically staged I-III in Sweden in 2007-2016. Exposure was at least two dispensations of ACEI, ARB or diuretics within 1 year prior to surgery. Outcome was 90-day readmission due to dehydration including acute renal failure.

Results: In total, 3252 patients were included with 1173 (36.1%) exposed to ACEI, ARB or diuretics. The cumulative incidence for 90-day readmission due to dehydration was 29.0% (151 of 520) for exposed versus 13.8% (98 of 712) for unexposed. The proportion of readmissions due to any reason was 44.3% (520 of 1173) for exposed compared to 34.2% (712 of 2079) for unexposed. The incidence rate ratio for readmission due to dehydration was 2.83 (95% c.i. 2.21 to 3.63, P < 0.001). The hazard rate ratio was 2.45 (95% c.i. 1.83 to 3.27, P < 0.001) after adjusting for age, gender and comorbidity.

Conclusion: Medication with ACEI, ARB or diuretics defines a vulnerable patient group with increased risk of readmission due to dehydration after ileostomy formation.

Titel:	Preoperative use of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers and diuretics increases the risk of dehydration after ileostomy formation: population-based cohort study.
Autor/in / Beteiligte Person:	de la Motte L ; Nordenvall, C ; Martling, A ; Buchli, C
Link:	Zum Volltext
Zeitschrift:	BJS open, Jg. 8 (2024-05-08), Heft 3
Veröffentlichung:	2021- : [Oxford] : Oxford University Press ; <i>Original Publication</i>: [Chichester, West Sussex, England] : John Wiley & Sons Ltd., [2017]-, 2024
Medientyp:	academicJournal
ISSN:	2474-9842 (electronic)
DOI:	10.1093/bjsopen/zrae051
Schlagwort:	Humans Male Female Aged Sweden epidemiology Middle Aged Risk Factors Rectal Neoplasms surgery Postoperative Complications epidemiology Postoperative Complications etiology Cohort Studies Aged, 80 and over Incidence Registries Preoperative Care methods Angiotensin Receptor Antagonists therapeutic use Angiotensin Receptor Antagonists adverse effects Angiotensin-Converting Enzyme Inhibitors adverse effects Angiotensin-Converting Enzyme Inhibitors therapeutic use Ileostomy adverse effects Dehydration epidemiology Patient Readmission statistics & numerical data Diuretics adverse effects Diuretics therapeutic use
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [BJS Open] 2024 May 08; Vol. 8 (3). MeSH Terms: Angiotensin Receptor Antagonists* / therapeutic use ; Angiotensin Receptor Antagonists* / adverse effects ; Angiotensin-Converting Enzyme Inhibitors* / adverse effects ; Angiotensin-Converting Enzyme Inhibitors* / therapeutic use ; Ileostomy* / adverse effects ; Dehydration* / epidemiology ; Patient Readmission* / statistics & numerical data ; Diuretics* / adverse effects ; Diuretics* / therapeutic use ; Humans ; Male ; Female ; Aged ; Sweden / epidemiology ; Middle Aged ; Risk Factors ; Rectal Neoplasms / surgery ; Postoperative Complications / epidemiology ; Postoperative Complications / etiology ; Cohort Studies ; Aged, 80 and over ; Incidence ; Registries ; Preoperative Care / methods References: Colorectal Dis. 2021 Jul;23(7):1721-1732. (PMID: 33783976) ; Colorectal Dis. 2020 Mar;22(3):269-278. (PMID: 31562789) ; BMJ. 2007 Oct 20;335(7624):806-8. (PMID: 17947786) ; Surg Today. 2020 Jul;50(7):703-710. (PMID: 31865459) ; Dis Colon Rectum. 2012 Feb;55(2):175-80. (PMID: 22228161) ; Updates Surg. 2019 Sep;71(3):515-521. (PMID: 30887466) ; Int J Colorectal Dis. 2014 Sep;29(9):1131-5. (PMID: 25026894) ; Ann Surg. 2017 Feb;265(2):379-387. (PMID: 28059966) ; Dis Colon Rectum. 2013 Aug;56(8):974-9. (PMID: 23838866) ; Acta Oncol. 2023 Apr;62(4):342-349. (PMID: 37029990) ; BJS Open. 2023 May 5;7(3):. (PMID: 37161674) ; Dis Colon Rectum. 2018 Nov;61(11):1297-1305. (PMID: 30239391) ; J Gastrointest Surg. 2013 Feb;17(2):298-303. (PMID: 23192425) ; Colorectal Dis. 2021 May;23(5):1071-1082. (PMID: 33539646) ; Tech Coloproctol. 2022 May;26(5):333-349. (PMID: 35192122) ; J Surg Res. 2017 Apr;210:204-212. (PMID: 28457330) ; BMC Surg. 2021 May 27;21(1):267. (PMID: 34044794) ; Int J Colorectal Dis. 2018 Mar;33(3):311-316. (PMID: 29374802) ; Clin Epidemiol. 2021 Jan 12;13:21-41. (PMID: 33469380) Grant Information: Swedish Cancer Society; Cancer Society in Stockholm; Swedish Cancer and Allergy Foundation (Cancer- och allergifonden); Regional Agreement on Medical Training and Clinical Research; Region Stockholm; Karolinska Institutet Substance Nomenclature: 0 (Angiotensin Receptor Antagonists) ; 0 (Angiotensin-Converting Enzyme Inhibitors) ; 0 (Diuretics) Entry Date(s): Date Created: 20240531 Date Completed: 20240531 Latest Revision: 20240603 Update Code: 20240603 PubMed Central ID: PMC11140823

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Preoperative use of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers and diuretics increases the risk of dehydration after ileostomy formation: population-based cohort study.