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Psoriasis vulgaris (PV) and Atopic dermatitis (AD) are the two major types of immune-mediated inflammatory skin disease (IMISD). Limited studies reported the association between Ubiquitin-conjugating enzyme E2 (UBE2) and IMISD. We employed a two-sample Mendelian randomization (MR) study to assess the causality between UBE2 and PV & AD. UBE2 association genome-wide association study (GWAS) data were collected. The inverse variance weighted (IVW) method was utilized as the principal method in our Mendelian randomization (MR) study, with additional using the MR-Egger, weighted median, simple mode, and weighted mode methods. The MR-Egger intercept test, Cochran's Q test, MR-Pleiotropy RESidual Sum and Outlier (MR-PRESSO) and leave-one-out analysis were conducted to identify heterogeneity and pleiotropy, colocalization analysis was also performed. The results showed that Ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) was causally associated with PV (OR = 0.909, 95% CI: 0.830-0.996, P = 0.040), Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) was causally associated with AD (OR = 0.799, 95% CI: 0.709-0.990, P < 0.001). Both UBE2V1 and UBE2L3 may play protective roles in patients with PV or AD, respectively. No other significant result has been investigated. No heterogeneity or pleiotropy was observed. This study provided new evidence of the relationship between UBE2V1 and PV, UBE2L3 and AD. Our MR suggested that UBE2V1 plays an inhibitory role in PV progression, UBE2L3 plays an inhibitory role in AD. These could be novel and effective ways to treat PV and AD.

Titel:	Role of Ubiquitin-conjugating enzyme E2 (UBE2) in two immune-mediated inflammatory skin diseases: a mendelian randomization analysis.
Autor/in / Beteiligte Person:	Wang, X ; Zhu, Z
Link:	Zum Volltext
Zeitschrift:	Archives of dermatological research, Jg. 316 (2024-05-25), Heft 6, S. 249
Veröffentlichung:	Berlin : Springer Verlag, 2024
Medientyp:	academicJournal
ISSN:	1432-069X (electronic)
DOI:	10.1007/s00403-024-02976-4
Schlagwort:	Humans Dermatitis, Atopic genetics Dermatitis, Atopic immunology Genetic Predisposition to Disease Genome-Wide Association Study Mendelian Randomization Analysis Polymorphism, Single Nucleotide Psoriasis genetics Psoriasis immunology Ubiquitin-Conjugating Enzymes genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Arch Dermatol Res] 2024 May 25; Vol. 316 (6), pp. 249. <i>Date of Electronic Publication: </i>2024 May 25. MeSH Terms: Dermatitis, Atopic* / genetics ; Dermatitis, Atopic* / immunology ; Genetic Predisposition to Disease* ; Genome-Wide Association Study* ; Mendelian Randomization Analysis* ; Polymorphism, Single Nucleotide* ; Psoriasis* / genetics ; Psoriasis* / immunology ; Ubiquitin-Conjugating Enzymes* / genetics ; Humans References: Antioxidants (Basel). 2022 Jun 27;11(7):. (PMID: 35883760) ; J Dermatol Sci. 2023 Sep;111(3):83-92. (PMID: 37349237) ; Expert Opin Drug Deliv. 2016 Oct;13(10):1461-73. (PMID: 27164301) ; J Invest Dermatol. 2023 May;143(5):822-831.e4. (PMID: 36502938) ; Cell Death Discov. 2022 Mar 24;8(1):130. (PMID: 35332135) ; Biology (Basel). 2021 Apr 28;10(5):. (PMID: 33924823) ; J Nanobiotechnology. 2020 May 6;18(1):68. (PMID: 32375794) ; Hepatology. 2019 May;69(5):1885-1902. (PMID: 30614547) ; Cell Biol Int. 2022 May;46(5):806-818. (PMID: 35128752) ; Biochem Biophys Rep. 2021 Aug 18;28:101108. (PMID: 34466666) ; Nucleic Acids Res. 2021 Jan 8;49(D1):D605-D612. (PMID: 33237311) ; Nat Immunol. 2018 Dec;19(12):1286-1298. (PMID: 30446754) ; Int J Epidemiol. 2015 Apr;44(2):496-511. (PMID: 25953784) ; Stat Med. 2017 May 20;36(11):1783-1802. (PMID: 28114746) ; J Virol. 2024 Feb 20;98(2):e0172623. (PMID: 38226814) ; Cureus. 2020 Aug 13;12(8):e9708. (PMID: 32944430) ; Exp Dermatol. 2018 Apr;27(4):340-357. (PMID: 29457272) ; Nature. 2018 Jun;558(7708):73-79. (PMID: 29875488) ; Nat Commun. 2022 May 31;13(1):3021. (PMID: 35641500) ; Cancer Lett. 2020 Jul 1;481:1-14. (PMID: 32268166) ; PLoS Genet. 2014 May 15;10(5):e1004383. (PMID: 24830394) ; Genes Immun. 2012 Jul;13(5):380-7. (PMID: 22476155) ; Physiol Rev. 2020 Oct 1;100(4):1599-1619. (PMID: 32666886) ; J Biol Chem. 2018 Aug 24;293(34):13191-13203. (PMID: 29950522) ; Int J Epidemiol. 2015 Apr;44(2):512-25. (PMID: 26050253) ; N Engl J Med. 2005 May 5;352(18):1899-912. (PMID: 15872205) ; FASEB J. 2022 Jan;36(1):e22103. (PMID: 34921695) ; Nat Genet. 2021 Oct;53(10):1415-1424. (PMID: 34594039) ; Nat Commun. 2023 Jul 20;14(1):4385. (PMID: 37474493) ; Circ Res. 2020 Mar 27;126(7):907-922. (PMID: 32081062) ; Cells. 2023 Dec 08;12(24):. (PMID: 38132113) ; Am J Transl Res. 2022 Jul 15;14(7):4549-4561. (PMID: 35958458) ; Nature. 2017 Sep 13;549(7671):293-295. (PMID: 28905898) ; BMJ. 2017 Dec 6;359:j5375. (PMID: 29212772) ; BMC Med. 2023 Feb 3;21(1):39. (PMID: 36737740) ; J Allergy Clin Immunol. 2023 May;151(5):1163-1168. (PMID: 36792449) ; Int J Biol Macromol. 2018 Nov;119:225-231. (PMID: 30041036) ; Int J Mol Sci. 2022 Nov 03;23(21):. (PMID: 36362243) ; J Eur Acad Dermatol Venereol. 2017 Aug;31(8):1271-1284. (PMID: 28419600) ; Curr Pharm Des. 2020;26(29):3619-3630. (PMID: 32160841) ; Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221082431. (PMID: 35243940) ; J Diabetes. 2024 Mar;16(3):e13511. (PMID: 38052719) ; Am J Hum Genet. 2022 May 5;109(5):767-782. (PMID: 35452592) Grant Information: S2023-JC-QN-0537 Natural Science Foundation of Shaanxi Province; YJ(QN) 202318 Youth Fund of the Second Affiliated Hospital of Xi'an Jiaotong University Contributed Indexing: Keywords: Atopic dermatitis; Causal inference; Mendelian randomization; Psoriasis vulgaris; Ubiquitin-conjugating enzyme E2 Substance Nomenclature: EC 2.3.2.23 (UBE2L3 protein, human) ; EC 2.3.2.23 (Ubiquitin-Conjugating Enzymes) ; EC 2.3.2.23 (UBE2V1 protein, human) Entry Date(s): Date Created: 20240525 Date Completed: 20240525 Latest Revision: 20240603 Update Code: 20240603 PubMed Central ID: PMC11127807

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Role of Ubiquitin-conjugating enzyme E2 (UBE2) in two immune-mediated inflammatory skin diseases: a mendelian randomization analysis.