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Background: Ubiquitin-conjugating enzyme E2 N (UBE2N) is recognized in the progression of some cancers; however, little research has been conducted to describe its role in prostate cancer. The purpose of this paper is to explore the function and mechanism of UBE2N in prostate cancer cells.

Methods: UBE2N expression was detected in Cancer Genome Atlas Prostate Adenocarcinoma (TCGA-PRAD) data, prostate cancer tissue microarrays, and prostate cancer cell lines, respectively. UBE2N knockdown or overexpression was used to analyze its role in cell viability and glycolysis of prostate cancer cells and tumor growth. XAV939 or Axin1 overexpression was co-treated with UBE2N overexpression to detect the involvement of the Wnt/β-catenin signaling and Axin1 in the UBE2N function. UBE2N interacting with Axin1 was analyzed by co-immunoprecipitation assay.

Results: UBE2N was upregulated in prostate cancer and the UBE2N-high expression correlated with the poor prognosis of prostate cancer. UBE2N knockdown inhibited cell viability and glycolysis in prostate cancer cells and restricted tumor formation in tumor-bearing mice. Wnt/β-catenin inhibition and Axin1 overexpression reversed the promoting viability and glycolysis function of UBE2N. UBE2N promoted Axin1 ubiquitination and decreased Axin1 protein level.

Titel:	UBE2N promotes cell viability and glycolysis by promoting Axin1 ubiquitination in prostate cancer cells.
Autor/in / Beteiligte Person:	Yang, B ; Chen, W ; Tao, T ; Zhang, J ; Kong, D ; Hao, J ; Yu, C ; Liao, G ; Gong, H
Link:	Zum Volltext
Zeitschrift:	Biology direct, Jg. 19 (2024-05-07), Heft 1, S. 35
Veröffentlichung:	[London] : BioMed Central, 2006-, 2024
Medientyp:	academicJournal
ISSN:	1745-6150 (electronic)
DOI:	10.1186/s13062-024-00469-y
Schlagwort:	Animals Humans Male Mice Cell Line, Tumor Mice, Nude Wnt Signaling Pathway Axin Protein metabolism Axin Protein genetics Cell Survival Glycolysis Prostatic Neoplasms metabolism Prostatic Neoplasms genetics Ubiquitin-Conjugating Enzymes metabolism Ubiquitin-Conjugating Enzymes genetics Ubiquitination
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Biol Direct] 2024 May 07; Vol. 19 (1), pp. 35. <i>Date of Electronic Publication: </i>2024 May 07. MeSH Terms: Axin Protein* / metabolism ; Axin Protein* / genetics ; Cell Survival* ; Glycolysis* ; Prostatic Neoplasms* / metabolism ; Prostatic Neoplasms* / genetics ; Ubiquitin-Conjugating Enzymes* / metabolism ; Ubiquitin-Conjugating Enzymes* / genetics ; Ubiquitination* ; Animals ; Humans ; Male ; Mice ; Cell Line, Tumor ; Mice, Nude ; Wnt Signaling Pathway References: Prostate. 2015 Oct;75(14):1586-600. (PMID: 26074449) ; Cell Rep. 2021 Dec 28;37(13):110175. (PMID: 34965427) ; Nat Rev Urol. 2017 Nov;14(11):683-696. (PMID: 28895566) ; Cancer Med. 2018 Aug;7(8):4012-4022. (PMID: 29989329) ; BMC Cancer. 2019 Jul 18;19(1):710. (PMID: 31319803) ; Cancer Res. 2018 Nov 15;78(22):6462-6472. (PMID: 30224375) ; Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13870-5. (PMID: 25189770) ; Cells. 2021 Apr 29;10(5):. (PMID: 33946927) ; Sci Rep. 2018 May 4;8(1):7050. (PMID: 29728578) ; J Oncol. 2022 Feb 21;2022:8264059. (PMID: 35237324) ; Cancer Cell Int. 2021 Nov 7;21(1):597. (PMID: 34743698) ; Klin Onkol. 2019 Fall;32(Supplementum 3):56-64. (PMID: 31627707) ; EBioMedicine. 2023 Jan;87:104397. (PMID: 36502574) ; Oncotarget. 2017 Dec 9;8(69):114072-114080. (PMID: 29371970) ; Anticancer Drugs. 2020 Jul;31(6):592-600. (PMID: 32427740) ; Front Oncol. 2020 Apr 08;10:493. (PMID: 32322560) ; Curr Oncol. 2022 Jul 18;29(7):5054-5076. (PMID: 35877260) ; Cells. 2024 Jan 31;13(3):. (PMID: 38334662) ; Cell. 2012 Jun 8;149(6):1245-56. (PMID: 22682247) ; Cell Death Dis. 2021 May 13;12(5):479. (PMID: 33980824) ; Cell Signal. 1999 Nov;11(11):777-88. (PMID: 10617280) ; Carcinogenesis. 2021 Feb 25;42(2):285-293. (PMID: 32930707) ; Theranostics. 2022 Jan 1;12(2):603-619. (PMID: 34976203) ; Cell Death Dis. 2021 Dec 1;12(12):1122. (PMID: 34853310) ; Onco Targets Ther. 2020 Dec 14;13:12751-12761. (PMID: 33363381) ; Sci Transl Med. 2022 Mar 9;14(635):eabb7695. (PMID: 35263148) ; J Immunol. 2021 May 15;206(10):2376-2385. (PMID: 33893171) ; Cell Death Dis. 2018 Jan 24;9(2):93. (PMID: 29367628) ; Biochem Biophys Res Commun. 2018 Sep 5;503(2):991-997. (PMID: 29932918) ; J Biosci. 2019 Sep;44(4):. (PMID: 31502580) ; Nat Med. 2014 Nov;20(11):1242-53. (PMID: 25375928) ; Eur Urol. 2009 Sep;56(3):486-94. (PMID: 18514389) ; Cancer Res. 2020 Sep 1;80(17):3519-3529. (PMID: 32665357) ; Kaohsiung J Med Sci. 2020 Jul;36(7):501-507. (PMID: 32196955) ; Cell Death Dis. 2014 Feb 20;5:e1079. (PMID: 24556694) ; Cell Biol Int. 2020 Aug;44(8):1651-1659. (PMID: 32285989) ; J Neurochem. 2024 Feb 27;:. (PMID: 38413218) ; Front Oncol. 2019 Nov 18;9:1248. (PMID: 31803621) Grant Information: PWRl2021-10 Leading Talent Project of Pudong New District Health System; 202150012 Foudation of Shanghai Municipal Health Commission Contributed Indexing: Keywords: Axin1; Glycolysis; Prostate cancer; UBE2N; Ubiquitination; Wnt/β-catenin Substance Nomenclature: 0 (Axin Protein) ; 0 (AXIN1 protein, human) ; EC 2.3.2.23 (Ubiquitin-Conjugating Enzymes) ; EC 2.3.2.23 (UBE2N protein, human) Entry Date(s): Date Created: 20240507 Date Completed: 20240508 Latest Revision: 20240510 Update Code: 20240510 PubMed Central ID: PMC11075218

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UBE2N promotes cell viability and glycolysis by promoting Axin1 ubiquitination in prostate cancer cells.